Abstract: Provided in some embodiments are methods of treating or preventing Raynaud's, comprising prescribing and/or administering to an individual in need thereof 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyloxy)methyl)cyclohexyl)methoxy)acetic acid (Compound 1), or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

Abstract: Rotary machines are disclosed that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: A nozzle assembly includes a mixing channel and an aerator. The mixing channel has upstream and downstream ends defining a flow direction through the mixing channel and includes a housing wall and a mixer. The housing wall defines a flow passage and includes an inlet portion and a tip orifice. The inlet portion disposed at the upstream end and configured to receive a first material and a second material. The tip orifice is disposed at the downstream end and is configured to emit a plural component material from the mixing channel. The mixer is disposed within the mixing channel and is configured to mix the first material and the second material into the plural component material. The aerator is configured to flow nucleation air to a location downstream of an upstream end of the mixer and into a flow of the plural component material.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: Computer display privacy and security for computer systems. In one aspect, the invention provides a computer-controlled system for regulating the interaction between a computer and a user of the computer based on the environment of the computer and the user. For example, the computer-controlled system provided by the invention comprises an input-output device including an image sensor configured to collect facial recognition data proximate to the computer. The system also includes a user security parameter database encoding security parameters associated with the user; the database is also configured to communicate with the security processor. The security processor is configured to receive the facial recognition data and the security parameters associated with the user, and is further configured to at least partially control the operation of the data input device and the data output device in response to the facial recognition data and the security parameters associated with the user.

Abstract: Computer display privacy and security for computer systems. In one aspect, the invention provides a computer-controlled system for regulating the interaction between a computer and a user of the computer based on the environment of the computer and the user. For example, the computer-controlled system provided by the invention comprises an input-output device including an image sensor configured to collect facial recognition data proximate to the computer. The system also includes a user security parameter database encoding security parameters associated with the user; the database is also configured to communicate with the security processor. The security processor is configured to receive the facial recognition data and the security parameters associated with the user, and is further configured to at least partially control the operation of the data input device and the data output device in response to the facial recognition data and the security parameters associated with the user.

Abstract: Computer display privacy and security for computer systems. In one aspect, the invention provides a computer-controlled system for regulating the interaction between a computer and a user of the computer based on the environment of the computer and the user. For example, the computer-controlled system provided by the invention comprises an input-output device including an image sensor configured to collect facial recognition data proximate to the computer. The system also includes a user security parameter database encoding security parameters associated with the user; the database is also configured to communicate with the security processor. The security processor is configured to receive the facial recognition data and the security parameters associated with the user, and is further configured to at least partially control the operation of the data input device and the data output device in response to the facial recognition data and the security parameters associated with the user.

Abstract: An apparatus for preparing a liquid material containing microbubbles includes a dispensing nozzle and a first positive displacement gas pump. The dispensing nozzles includes a material mixing channel, a rotary gas diffuser positioned in the material mixing channel, and a rotary mixer positioned in the material mixing channel downstream of the rotary gas diffuser. The rotary gas diffuser and the rotary mixer rotate about a common axis of rotation. The first positive displacement pump has a first gas outlet opening to the material mixing channel, which is directed at an outer circumference of the rotary gas diffuser.

Abstract: A rotary machine is provided which includes a chamber. The chamber includes an island having an island outer surface. The outer surface is an elongated convex shape. The island includes a crankshaft port. The chamber includes a front-plate attached to a front surface of the island. A concave shaped contour is included, which is biased toward the island outer surface and which rotates with respect to the island. A working volume is defined between an inner surface of the contour and the outer island surface. At least one front-plate engaging bearing is provided, which extends from a front surface of the movable contour and over a guide edge of the front-plate. The front-plate engaging bearing engages the guide edge during a combustion cycle.

Abstract: A system and method for nondestructive detection of gas in a sealed container. The system includes a light source housed in a light source housing and configured to emit a light beam for absorption in a substance to be measured, a detector housed in a detector housing and configured to detect the emitted light beam, a zone that accepts one or more of the sealed containers, each container being substantially optically transparent and containing the substance to be measured, the zone located between the detector and the light source, the light source configured to transmit the light beam through the zone, and a light source purging system comprising a light source channel surrounding the light source and positioned between the light source and the housing, the light source channel configured to expel purge gas from a purge gas source into the zone.

Abstract: A rotary machine is provided which includes a chamber. The chamber includes an island having an island outer surface. The outer surface is an elongated convex shape. The island includes a crankshaft port. The chamber includes a front-plate attached to a front surface of the island. A concave shaped contour is included, which is biased toward the island outer surface and which rotates with respect to the island. A working volume is defined between an inner surface of the contour and the outer island surface. At least one front-plate engaging bearing is provided, which extends from a front surface of the movable contour and over a guide edge of the front-plate. The front-plate engaging bearing engages the guide edge during a combustion cycle.

Abstract: An inverse displacement asymmetric rotary engine is provided which includes a chamber. The chamber includes a stationary island having an island outer surface. The outer surface is an elongated convex shape. The island includes a crankshaft port spaced from a center of the island. The chamber includes a front-plate attached to a front surface of the island. A concave shaped movable contour is include, which is biased toward the island outer surface and which revolves about the island. A working volume is defined between an inner surface of the contour and the outer island surface. At least one front-plate engaging bearing is provided, which extends from a front surface of the movable contour and over a guide edge of the front-plate. The front-plate engaging bearing engages the guide edge during a combustion cycle.

Abstract: A system and method for nondestructive detection of gas in a sealed container. The system includes a light source housed in a light source housing and configured to emit a light beam for absorption in a substance to be measured, a detector housed in a detector housing and configured to detect the emitted light beam, a zone that accepts one or more of the sealed containers, each container being substantially optically transparent and containing the substance to be measured, the zone located between the detector and the light source, the light source configured to transmit the light beam through the zone, and a light source purging system comprising a light source channel surrounding the light source and positioned between the light source and the detector housing, the light source channel configured to expel purge gas from a purge gas source into the zone.

Abstract: Methods and apparatus for displaying visual content on a display such that the content is comprehensible only to an authorized user for a visual display system such as a computer, a television, a video player, a public display system (including but not limited to a movie theater), a mobile phone, an automated teller machine (ATM), voting booths, kiosks, security screening workstations, tactical displays and other systems where information is displayed for viewing.

Abstract: An inverse displacement asymmetric rotary engine is provided which includes a chamber. The chamber includes a stationary island having an island outer surface. The outer surface is an elongated convex shape. The island includes a crankshaft port spaced from a center of the island. The chamber includes a front-plate attached to a front surface of the island. A concave shaped movable contour is include, which is biased toward the island outer surface and which revolves about the island. A working volume is defined between an inner surface of the contour and the outer island surface. At least one front-plate engaging bearing is provided, which extends from a front surface of the movable contour and over a guide edge of the front-plate. The front-plate engaging bearing engages the guide edge during a combustion cycle.

Abstract: Computer display privacy and security for computer systems. In one aspect, the invention provides a computer-controlled system for regulating the interaction between a computer and a user of the computer based on the environment of the computer and the user. For example, the computer-controlled system provided by the invention comprises an input-output device including an image sensor configured to collect facial recognition data proximate to the computer. The system also includes a user security parameter database encoding security parameters associated with the user; the database is also configured to communicate with the security processor. The security processor is configured to receive the facial recognition data and the security parameters associated with the user, and is further configured to at least partially control the operation of the data input device and the data output device in response to the facial recognition data and the security parameters associated with the user.

Abstract: Methods and apparatus for displaying visual content on a display such that the content is comprehensible only to an authorized user for a visual display system such as a computer, a television, a video player, a public display system (including but not limited to a movie theater), a mobile phone, an automated teller machine (ATM), voting booths, kiosks, security screening workstations, tactical displays and other systems where information is displayed for viewing.