Patents by Inventor William R. Baumbach
William R. Baumbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230191090Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for stent deployment, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: February 15, 2023Publication date: June 22, 2023Applicant: Caliber Therapeutics, LLCInventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Publication number: 20210386979Abstract: A balloon catheter system for infusion of micelles at high pressure. The system includes a catheter with a drug eluting balloon with a perforated wall with numerous pores, a reservoir of nanoparticles in an aqueous solution disposed within the balloon or in fluid communication with the balloon. The particles may comprise drug loaded micelles, where the micelles are provided in the size range of 40 to 250 nm generally (0.040 ?m to 0.250 ?m), and the pores of the balloon wall are configured to allow passage of the micelles with a minimum of disruption, The pores are conical, with the diameter of the pore at the inside of the balloon wall smaller than the diameter of the pores at the outside of the balloon wall.Type: ApplicationFiled: September 26, 2019Publication date: December 16, 2021Applicant: Caliber Therapeutics, LLCInventors: William R. BAUMBACH, Darren R. SHERMAN
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Publication number: 20210046292Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: October 20, 2020Publication date: February 18, 2021Applicant: Caliber Therapeutics, LLCInventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 10806909Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: August 28, 2018Date of Patent: October 20, 2020Assignee: Caliber Therapeutics, LLCInventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 10207084Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: May 12, 2017Date of Patent: February 19, 2019Assignee: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Publication number: 20180361124Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: August 28, 2018Publication date: December 20, 2018Applicant: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Publication number: 20170246432Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: May 12, 2017Publication date: August 31, 2017Applicant: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 9649478Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: April 7, 2014Date of Patent: May 16, 2017Assignee: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 9649479Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: March 23, 2016Date of Patent: May 16, 2017Assignee: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Publication number: 20160199624Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: March 23, 2016Publication date: July 14, 2016Applicant: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Publication number: 20140221978Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 8715230Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: April 2, 2013Date of Patent: May 6, 2014Assignee: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert S. Burgermeister
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Patent number: 8696644Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: GrantFiled: December 30, 2010Date of Patent: April 15, 2014Assignee: Caliber Therapeutics, Inc.Inventors: William R. Baumbach, Darren R. Sherman, Robert Burgermeister
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Publication number: 20140039389Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: April 2, 2013Publication date: February 6, 2014Inventors: William R. Baumbach, Darren R. Sherman, Robert Burgermeister
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Publication number: 20110166547Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.Type: ApplicationFiled: December 30, 2010Publication date: July 7, 2011Inventors: William R. Baumbach, Darren R. Sherman, Robert Burgermeister
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Publication number: 20090220564Abstract: The present disclosure provides methods and compositions for treating coronary tissue damaged as a result of a cardiac disorder such as ischemia, acute myocardial infarction, vulnerable plaques, or reperfusion injury. Specifically, the cardiac disorder is treated using a multivalent molecule that is specific for a marker located, in or near the damaged coronary tissue and a marker located on a target cell (e.g., a stem cell). The multivalent molecule may be administered by intravenous injection, intra-arterial catheter, intramyocardial injection, or implantable device (e.g, stent).Type: ApplicationFiled: August 18, 2006Publication date: September 3, 2009Inventors: William R. Baumbach, Hariharan Shankar, Oded Ben-Joseph
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Patent number: 6342499Abstract: The present invention provides a method to control parasitic and saprophagous mites on beneficial insects such as honeybees via the application of a parasiticidally or saprophagouscidally effective amount of a mitochondrial electron transport inhibitor or a pyrimidine compound of formula I.Type: GrantFiled: July 12, 1999Date of Patent: January 29, 2002Assignee: BASF AktiengesellschaftInventors: Bruce Christian Black, William R. Baumbach, Michael P. Beluch
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Patent number: 6204283Abstract: The present invention provides a method to control parasitic mites on beneficial insects, such as honeybees, via the application of a parasiticidally effective amount of tebufenpyrad.Type: GrantFiled: July 12, 1999Date of Patent: March 20, 2001Assignee: American Cyanamid CompanyInventors: Bruce Christian Black, William R. Baumbach, Michael P. Beluch
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Patent number: 5583010Abstract: Growth hormone releasing hormone (GHRH) receptor binding has been characterized using a unique binding assay utilizing iodinated GHRH probes. Photoaffinity GHRH probes have been constructed which allow for photolabeling and characterization of the receptor. In addition, high affinity biotinylated GHRH analogs have been constructed. Solubilization of GHRH-R/GHRH complexes and extraction of specifically bound GHRH using a mild detergent solution, followed by affinity chromotography, leads to a substantially purified GHRH-R isolate. Electrophoretic treatment of the GHRH-R isolate produces GHRH-R of sufficient purity to conduct sequencing of the receptor. Cloning of a gene encoding for polypeptides (protein or fragments thereof) having GHRH-R activity is accomplished using a bacterial host, and the cloned gene is expressed in a mammalian cell line.Type: GrantFiled: June 10, 1993Date of Patent: December 10, 1996Assignees: American Cyanamid Company, The University of Virginia Patent FoundationInventors: William R. Baumbach, John R. Zysk, Michael O. Thorner, Bruce D. Gaylinn, Kevin R. Lynch, Jeffrey K. Harrison
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Patent number: 5439795Abstract: The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.Type: GrantFiled: January 31, 1990Date of Patent: August 8, 1995Assignee: American Cyanamid CompanyInventors: William R. Baumbach, Bosco S. Wang, Homayoun Sadeghi, John S. Logan, Ian C. Hart