Patents by Inventor William R. Bishai

William R. Bishai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MYCOBACTERIUM TUBERCULOSIS PERSISTANCE GENES
    Publication number: 20080241182
    Abstract: Compositions and methods for preventing Mycobacterium infections, particularly persistent, latent Mycobactial infections, are provided. The compositions and methods utilize newly identified Mycobacterium genes (and/or corresponding gene products) that are necessary for survival of Mycobacteriae within a host.
    Type: Application
    Filed: January 18, 2008
    Publication date: October 2, 2008
    Inventors: Sanjay K. Jain, S. Moises Hernandez-Abanto, Gyanu Lamichhane, William R. Bishai
  • whmD, an essential cell division gene from mycobacteria
    Patent number: 6590087
    Abstract: A whmD gene that controls sporulation in mycobacteria, vectors and transformed cells containing the gene.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: July 8, 2003
    Assignee: Johns Hopkins University
    Inventors: William R. Bishai, James E. Gomez
  • Method of identifying compounds that regulate the binding of M. tuberculosis sigF to M. tuberculosis orfX
    Patent number: 6004764
    Abstract: sigF is a gene that controls M. tuberculosis latency. A diagnostic test for latent tuberculosis involves detecting M. tuberculosis sigF in clinical specimens. Two genes orfX and orfY regulate sigF expression and sigF activity. M. tuberculosis sigF, orfX, and orfY are used in screening methods for potential therapeutic agents which regulate the growth of M. tuberculosis.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: December 21, 1999
    Assignee: Johns Hopkins University
    Inventors: William R. Bishai, Douglas B. Young, Ying Zhang, James DeMaio
  • Regulation of a sigma factor from Mycobacterium tuberculosis
    Patent number: 5824546
    Abstract: Two genes, orfX and orfY, regulate sigF expression and sigF activity in M. tuberculosis. M. tuberculosis sigF, orfX, and orfY are used in screening methods for potential therapeutic agents which regulate the growth of M. tuberculosis.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: October 20, 1998
    Assignee: The Johns Hopkins University
    Inventors: William R. Bishai, James DeMaio
  • DNA encoding stationary phase, stress response sigma factor from Mycobacterium tuberculosis
    Patent number: 5700925
    Abstract: SigF is a gene that controls M. tuberculosis latency. A diagnostic test for latent tuberculosis involves detecting M. tuberculosis sigF in clinical specimens. A tuberculosis vaccine includes a M. tuberculosis strain with a mutation which disrupts the reading frame of its sigF gene.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: December 23, 1997
    Assignee: The Johns Hopkins University
    Inventors: William R. Bishai, Douglas B. Young, Ying Zhang, James DeMaio