Abstract: The present invention describes ophthalmic lipoic acid choline ester compositions and specific processes to produce biocompatible formulations of said compositions suitable for the eye.

Abstract: A method, computer program product, and computer system for receiving, at a computing device, a plurality of development requirements of a software development project. A plurality of possible results for one or more development factors estimated to complete the software development project may be generated based upon, at least in part, the plurality of development requirements for the software development project. A plurality of results for the one or more development factors estimated to complete the software development project may be generated and may include processing a different set of random values from the plurality of possible results for the one or more development factors estimated to complete the software development project during each iteration of a plurality of iterations of one or more probabilistic models. The plurality of results for the one or more development factors may be provided in a user interface.

Abstract: Provided herein are pharmaceutical compositions comprising a therapeutically effective amount of lipoic acid choline ester or derivatives thereof and a non-aqueous excipient mixed in an aqueous solution. Also provided herein are non-aqueous compositions prepared by mixing the therapeutically effective amount of lipoic acid choline ester and the non-aqueous excipient. The non-aqueous compositions can be further mixed with the aqueous solution.

Abstract: Embodiments of the present invention relate to methods and pharmacological or biological compositions to treat presbyopia in the human eye. According to the embodiments, pharmacological or biological compositions may be applied to or injected into an eye to effect a change in the accommodative ability of the eye by the breaking and reduction of lenticular bonds in the eye that may be responsible for presbyopia. The compositions may be applied in an inactive state and subsequently be activated to achieve a therapeutic effect. The application of energy may be used to either break the oxidized lenticular bonds and/or to activate one or more of the pharmacological or biological agents. The energy may be used in a focus treatment pattern to affect a change in the refractive characteristics of the eye and thereby reduce inherent optical distortions.

Abstract: Embodiments of the present invention relate to methods and pharmacological or biological compositions to treat presbyopia in the human eye. According to the embodiments, pharmacological or biological compositions may be applied to or injected into an eye to effect a change in the accommodative ability of the eye by the breaking and reduction of lenticular bonds in the eye that may be responsible for presbyopia. The compositions may be applied in an inactive state and subsequently be activated to achieve a therapeutic effect. The application of energy may be used to either break the oxidized lenticular bonds and/or to activate one or more of the pharmacological or biological agents. The energy may be used in a focus treatment pattern to affect a change in the refractive characteristics of the eye and thereby reduce inherent optical distortions.

Abstract: A broadband, electrooptic modulator is disclosed which, in a first embodiment, comprises: a substrate having substrate modes, having electrooptic effects, and having a first optical waveguide adapted to receive and transmit light therethrough in a first direction and with a first phase velocity; a buffer layer disposed on the substrate; and a coplanar waveguide electrode structure having a coplanar mode and being disposed on the buffer layer for receiving an electrical signal propagating therethrough in the first direction with a second phase velocity to phase modulate the light in the optical waveguide at a frequency in the range from 0 Hz up to substantially 40 GHz.

Abstract: A cervical collar including front and back halves adapted to fit around the neck, and an adjustable strap for releasably securing the halves in position on the neck. The halves of the collar are made from a laminate having outer layers of a foamed polymeric material and an inner layer of a solid, non-foamed thermoplastic material. The foam layes provide padding and comfort, and the solid layers provide rigidity and support to immobilize the head and neck. In one embodiment there is provided a large hole in the front most portion of the collar to accommodate the Adam's apple. In another embodiment, the strap is attached to the back half by looping it through parallel slots formed in the rearmost portion of the collar which are narrower than the width of the strap adjacent the slots, and attached to the front half by stitching at the ends thereof.

Abstract: A cervical collar including front and back halves adapted to fit around the neck, and an adjustable strap for releasably securing the halves in position on the neck. The halves of the collar are made from a laminate having outer layers of a foamed polymeric material and an inner layer of a solid, non-foamed thermoplastic material. The foam layes provide padding and comfort, and the solid layers provide rigidity and support to immobilize the head and neck. In one embodiment there is provided a large hole in the front most portion of the collar to accommodate the Adam's apple. In another embodiment, the strap is attached to the back half by looping it through parallel slots formed in the rearmost portion of the collar which are narrower than the width of the strap adjacent the slots, and attached to the front half by stitching at the ends thereof.