Abstract: Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

Abstract: A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum.

Abstract: A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum.

Abstract: A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum.

Abstract: A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum.

Abstract: A laser beam steering apparatus includes a beam steering cell with an adjustable shape, with the cell having opposing Fabry-Perot filters, and a steering mechanism coupled to the cell to adjust its shape so that the direction of a laser beam emitted from the cell is changed in response to a change in the cell shape.

Abstract: An optical power converting apparatus is provided that may be used with remote sensors. A plurality of remote sensors may be coupled to a backbone optical fiber with each sensor having an optical power converter that receives an optical signal from a head end of that fiber. The optical power converters may store electrical energy derived from that optical signal and use that energy to power the remote sensors. The head end's optical signal may also include a clock signal, and each remote sensor may be set to sense a measurable parameter after a given number of clock cycles have been counted. In a further example, each of the optical sensors may be synchronized before counting these clock signals via a synchronization signal from the optical power converter. The remote sensors may individually and separately uplink their sensed data to the head end on the optical fiber. The apparatus may be implemented in a vehicle health management system, for example.

Abstract: An optical power converting apparatus is provided that may be used with remote sensors. A plurality of remote sensors may be coupled to a backbone optical fiber with each sensor having an optical power converter that receives an optical signal from a head end of that fiber. The optical power converters may store electrical energy derived from that optical signal and use that energy to power the remote sensors. The head end's optical signal may also include a clock signal, and each remote sensor may be set to sense a measurable parameter after a given number of clock cycles have been counted. In a further example, each of the optical sensors may be synchronized before counting these clock signals via a synchronization signal from the optical power converter. The remote sensors may individually and separately uplink their sensed data to the head end on the optical fiber. The apparatus may be implemented in a vehicle health management system, for example.

Abstract: A pulsed diode ring laser gyroscope and method of modulation are provided to greatly reduce the occurrence of frequency locking in optical gyroscopes at low rotational rates. One or two optical diodes serve as optical amplifiers for a pair of counterpropagating optical pulses circulating in an optical ring resonator. The amplifiers are driven twice each round trip (once for each pulse) using pulses much shorter than the round trip time. The short optical pulses overlap in regions of the resonator generally isolated from light scattering elements. The pulses are produced by gain switching the optical amplifiers with an electrical current pulse train having a fundamental period synchronous with the optical round trip time in the resonator cavity. With this modulation scheme, the diodes can be thought of as gates that open twice each round trip-once for each of the counterpropagating pulses. During each on time, the diodes amplify only a clockwise or counterclockwise pulse.