Abstract: In some embodiments, a computer system applies a time of day setting to a virtual environment. In some embodiments, the time of day setting is updated based on an event. In some embodiments, a computer system displays content in an expanded display mode. In some embodiments, computer systems join a communication session while maintaining display of respective environments. In some embodiments, a computer system moves a portal based on user movement. In some embodiments, computer systems share a virtual environment. Computer systems can display media with simulated lighting. Computer systems can share an environment. In some embodiments, a computer system selects a position relative to content. A computer system can present representations of communication session participants based on content. A computer system can present user interfaces to control visual appearances of an environment including media. Computer systems can change an appearance of an environment based on environmental modes.

Abstract: The invention provides ?-mimetic structure of formula (I), wherein A is —(C?O)—(CHR3)— or —(C?O)—; B is —(NR5)— or —(CHR6)—; D is —(C?O)—(CHR7)— or —(C?O)—; E is -(ZR8)— or —(C?O)—, where Z is nitrogen or CH; —(XR9)n—, —(CHR10)—(NR6)—, —(C?O)—(XR12)—, —(C?N—W—R1)—, —(C?O)—, —(X—(C?O)—R13)—, —(X—(C?O)—NR13R14)—, —(X—(SO2)—R13)—, or —(X—(C?O)—OR13)—, where X is nitrogen or CH, and n=0 or 1; W is —Y(C?O)—, —(C?O)—(NH)—, —(SO2)—, —(CHR14)—, —(C?O)—(NR15)—, substituted or unsubstituted oxadiazole, substituted or unsubstituted triazole, substituted or unsubstituted thiadiazole, substituted or unsubstituted 4,5-dihydrooxazole, substituted or unsubstituted 4,5-dihydrothiazole, substituted or unsubstituted 4,5-dihydroimidizole, or nothing, where Y is oxygen or sulfur; and R1, R2, R3, R4, R5, R6, R7, R8, R9 R10, R11, R12, R13, R14, and R15 are the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and ster

Abstract: A lighting assembly for a vehicle includes an elongated base plate having an inner surface and an outer surface. The base plate includes at least one opening. The lighting assembly further includes at least one light source adapted to be mounted to the base plate at the opening. The base plate is configured to be mounted and to conform aerodynamically to an exterior surface of the vehicle.

Abstract: The invention provides ?-mimetic structure of formula (I), wherein A is —(C?O)—(CHR3)— or —(C?O)—; B is —(NR5)— or —(CHR6)—; D is —(C?O)—(CHR7)— or —(C?O)—; E is -(ZR8)— or —(C?O)—, where Z is nitrogen or CH; —(XR9)n—, —(CHR10)—(NR6)—, —(C?O)—(XR12)—, —(C?N—W—R1)—, —(C?O)—, —(X—(C?O)—R13)—, —(X—(C?O)—NR13R14)—, —(X—(SO2)—R13)—, or —(X—(C?O)—OR13)—, where X is nitrogen or CH, and n=0 or 1; W is —Y(C?O)—, —(C?O)—(NH)—, —(SO2)—, —(CHR14)—, —(C?O)—(NR15)—, substituted or unsubstituted oxadiazole, substituted or unsubstituted triazole, substituted or unsubstituted thiadiazole, substituted or unsubstituted 4,5-dihydrooxazole, substituted or unsubstituted 4,5-dihydrothiazole, substituted or unsubstituted 4,5-dihydroimidazole, or nothing, where Y is oxygen or sulfur; and R1, R2, R3, R4, R5, R6, R7, R8, R9 R10, R11, R12, R13, R14, and R15 are the same or different and independently selected from an amino acid side chain moiety or derivative thereof, the remainder of the molecule, a linker and a solid support, and ster

Abstract: The invention provides ?-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, R1 and R2 as set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the treatment of fibrotic diseases, such as pulmonary fibrosis.

Abstract: The invention provides ?-helix mimetic structures of formula (I) with the definitions of A, B, D, E, G, W, R1 and R2 as set out in the description and a chemical library relating thereto. The compounds, pharmaceutical compositions comprising the compounds, and methods of the invention using the compounds, relate to the reversal of fibrotic conditions, such as pulmonary fibrosis.

Abstract: An article carrier apparatus for a vehicle includes a cross rail interconnected to an exterior surface of the vehicle, a heat sink positioned within the cross rail, and a light source positioned within the cross rail. The light source is thermally connected to the heat sink such that the heat sink will absorb at least a portion of the heat generated by operation of the light source. The cross rail will structurally support an article attached to the exterior of a vehicle.

Abstract: Spoked wheel assemblies (22, 55) having included angles (50, 70) about a center line (20) passing through tire rims (25, 78) and a midway point on a distance between forks, yielding uniform tension in their sets of spokes (30, 31/76, 77) forming the included angles (50, 70) that are equally divided about their corresponding line (20). A front wheel hub assembly (37) includes a housing 27, a web 28 mounted thereon and passing through the center line (20), a circumferential member (29) mounted to web (28), and a pair of flanges (23) spacedly mounted on member (29). Openings (34) are provided in assembly (37) to lessen weight.

Abstract: A system of combining any one of a plurality of driving modules (e.g., electric motors) with any one of a plurality of driven modules (e.g., speed reducers) is disclosed. Each of the driving modules has an output shaft and each of the driven modules has an input shaft. One of these shafts of the combined driving module and driven module combination has a tapered outer surface, and the other of these shafts has a tapered socket therein, with the tapered outer shaft being coaxially received within the tapered socket, and with the taper of the outer surface and the taper of the socket being substantially the same. A draw screw is provided for locking the shafts in coaxial coupled relation. Driving modules are directly connected to driven modules through frame mating surfaces and the aforementioned tapered shaft/socket connection. When the driven module is assigned a mechanical service factor of 1.0 or greater, an adapter is interposed between the driving and driven modules.