Patents by Inventor William R. Herzog, Jr.

William R. Herzog, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Medical device coated with a polymer containing a nitric oxide releasing organometallic nitrosyl compound useful for the prevention of platelet aggregation
    Patent number: 6656217
    Abstract: The aggregation of platelets on the surface of a foreign body exposed to the flowing blood of a living being (such as plastic tubing, a balloon or the end of a catheter surgically inserted in a blood vessel, a stent implanted therein or synthetic grafts, which surface normal promotes such platelet aggregation to form a coating firmly affixed to that surface which would restrict the flow of blood past that surface or to form a blood clot detachable from that surface), is inhibited by a gas permeable coating on the surface of a physiologically acceptable polymer as which contains dissolved or dispersed therein a nitrosyl-containing organometallic compound, such as sodium nitroprusside, which is protected from diffusion from the coating and from direct contact with the blood and which slowly decomposes at the body temperature within the coating and in so doing releases a platelet aggregation-inhibiting amount of nitric oxide which diffuses from the coating during the period when platelet aggregation by the surfa
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: December 2, 2003
    Assignee: NovoVascular, Inc.
    Inventors: William R. Herzog, Jr., Sovitj Pou, Gerald M. Rosen, Yi-Ju Zhao
  • Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
    Patent number: 5797887
    Abstract: A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a layer affixed to that surface and thus restrict the flow of blood past that surface or to form a blood clot detachable from that surface which when detached could trigger a stroke, heart attack or partial loss of organ function, such as plastic tubing, a balloon or the end of a catheter surgically inserted in a blood vessel or a stent implanted therein, e.g.
    Type: Grant
    Filed: August 27, 1996
    Date of Patent: August 25, 1998
    Assignee: Novovasc LLC
    Inventors: Gerald M. Rosen, William R. Herzog, Jr., Sovitj Pou
  • Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis
    Patent number: 5665077
    Abstract: A surface of a foreign body exposed to the flowing blood of a living being which normally would promote the aggregation of platelets in that blood to form a coating firmly affixed to that surface and thus restrict the flow of blood past that surface or to form a blood clot detachable from that surface which when detached could trigger a stroke, heart attack or partial loss of lung function, such as plastic tubing, a balloon or the end of a catheter surgically inserted in a blood vessel or a stem implanted therein, e.g.
    Type: Grant
    Filed: April 24, 1995
    Date of Patent: September 9, 1997
    Assignee: Nitrosci Pharmaceuticals LLC
    Inventors: Gerald M. Rosen, William R. Herzog, Jr., Sovitj Pou