Patents by Inventor William R. McCombie

William R. McCombie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Octopamine receptor
    Patent number: 5474898
    Abstract: The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: December 12, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John C. Venter, Claire M. Fraser, William R. McCombie
  • DNA encoding an insect octopamine receptor
    Patent number: 5344776
    Abstract: The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: September 6, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John C. Venter, Claire M. Fraser, William R. McCombie