Abstract: Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.

Abstract: Natural sweetener compositions, comprising a highly purified steviol extract of rebaudioside A (Reb A) of about 80 to 99% purity, other steviol glycosides of about 3% or less, and sterebins of 1% or less, and one or more bulking agents, where the natural sweetener compositions are suitable for use as an ingredient in orally administered pharmaceuticals, foods, beverages, and other orally administered products, for humans and animals. A method of preparing naturally sweetened orally administered products, comprising the step of mixing natural sweetener compositions, having a highly purified steviol extract and one or more bulking agents, with other ingredients commonly used in manufacturing orally administered products.

Abstract: Antifungal nail coat compositions containing an allylamine, an N,N-di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester or a pharmaceutically acceptable acid addition salt thereof, a hydrophilic polymer, and a pharmaceutically acceptable, volatile organic carrier are disclosed. The composition provides a substantially water-soluble, fungicidal coating upon contact with a fungally susceptible or infected nail.

Abstract: A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.

Abstract: A two-dimensional focal plane array (FPA) is divided into sub-arrays of rows and columns of pixels, each sub-array being responsive to light energy from a target object which has been separated by a spectral filter or other spectrum dividing element into a predetermined number of spectral bands. There is preferably one sub-array on the FPA for each predetermined spectral band. Each sub-array has its own read out channel to allow parallel and simultaneous readout of all sub-arrays of the array. The scene is scanned onto the array for simultaneous imaging of the terrain in many spectral bands. Time Delay and Integrate (TDI) techniques are used as a clocking mechanism within the sub-arrays to increase the signal to noise ratio (SNR) of the detected image. Additionally, the TDI length (i.e., number of rows of integration during the exposure) within each sub-array is adjustable to optimize and normalize the response of the photosensitive substrate to each spectral band.

Abstract: A two-dimensional focal plane array (FPA) is divided into sub-arrays of rows and columns of pixels, each sub-array being responsive to light energy from a target object which has been separated by a spectral filter or other spectrum dividing element into a predetermined number of spectral bands. There is preferably one sub-array on the FPA for each predetermined spectral band. Each sub-array has its own read out channel to allow parallel and simultaneous readout of all sub-arrays of the array. The scene is scanned onto the array for simultaneous imaging of the terrain in many spectral bands. Time Delay and Integrate (TDI) techniques are used as a clocking mechanism within the sub-arrays to increase the signal to noise ratio (SNR) of the detected image. Additionally, the TDI length (i.e., number of rows of integration during the exposure) within each sub-array is adjustable to optimize and normalize the response of the photosensitive substrate to each spectral band.

Abstract: Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of an active agent and a mucosal adhesion enhancer; wherein the active agent is encapsulated within a polymer which is chemically or physically distinct from the hydocolloid; wherein the mucosal adhesion enhancer is a starch graft copolymer; wherein the film exhibits a dry tack value of less than 3.5 g, a wet tack of greater than 35 g, a gelation temperature that is greater than 70° C. for a 2% polymer solution, a dry film thickness of less than 20 mil, a water content of 0.5 to 10%, a tensile strength greater than 1500 psi, a modulus in the range of 35,000 to 300,000 psi, a % elongation of less than 20%, a tear probagation resistance of 0.001 to 1 N, and a dissolution time in the range of 1 to 600 seconds upon application to an oral mucosal surface.

Abstract: Mucosal surface-coat-forming film dosage units containing a water-soluble hydrocolloid, an effective dose of a sexual dysfunction active agent and a mucosal adhesion enhancer, wherein the mucosal adhesion enhancer is a starch graft copolymer.

Abstract: An electro-optical imaging array having pixels arranged in rows and columns electronically compensates for image motion in the plane of the array regardless of whether the motion vector is in the row direction, the column direction, or in a diagonal direction, i.e., in some vector combination of row and column directions. In an aerial reconnaissance application, the image motion may be due to rotation of the aircraft about roll, pitch and/or yaw angles in addition to forward velocity of the aircraft. The image motion compensation is achieved with no moving parts and does not require a stabilized platform.A camera control computer determines the magnitude and direction of the image motion from inertial navigation system inputs, including velocity, flight, and aircraft rotation information, and calculates pixel information transfer rates in the row and column directions. The pixel information transfer rates are supplied to a counter and clock driver circuit for the array.

Abstract: A transdermal delivery system for the modulated administration of drugs is described. The drug delivery device comprises a backing; a drug reservoir containing the drug, a plasticizer-type enhancer, a solvent-type enhancer, and optionally, a gelling agent; a non-rate-controlling membrane; and an adhesive layer containing a plasticizer-type enhancer. This drug delivery system is particularly useful for the administration of tolerance-inducing drugs, for example, vasodilators, such as isosorbide dinitrate.

Abstract: Tapping apparatus for tapping holes in workpieces is provided with a tap assembly that includes a tap fitted to a lower tip end of a vertical lead screw, there being means including a bushing for rotating the lead screw thereby to vertically advance and retract the tap relative to the a workpiece hole. Power operating means are provided to rapidly advance and retract the lead screw independently of rotating advance/retraction of the lead screw so as to more quickly locate the tap proximal the workpiece hole allowing that tapping commences with lessened need for lead screw rotation as a means of effecting lineal advance of the lead screw. This lessens the tapping cycle time and results in increased production rate with the apparatus as well as lengthening tap life.

Abstract: A silicone pressure sensitive adhesive composition which is compatible with drugs, excipients, co-solvents and skin penetration enhancers is disclosed which includes a cohesive strengthening agent in combination with a silicone fluid and a silicate resin. The addition of the cohesive strengthening agent helps to maintain the adhesive on the substrate, while reducing cold flow. The adhesive is useful as an improved component in transdermal drug delivery devices and related medical devices.

Abstract: Improved apparatus and methods of image information processing are disclosed which extend the operational coverage of an image system to higher velocity to height ratio scenarios while optimizing image resolution. The invention typically is implemented by a time delay and integrate charge-coupled device. In conjunction with an image variable row scan rate, a novel method of clocking the device is used to adjust the number of cycles of clocking performed in one row read out time, and to simultaneously transfer pixel information located in a plurality of rows of an imaging array having a predetermined row relationship. The relationship between the variable row scan rate, the predetermined row relationship and the number of cycles of clocking is adjusted so that the scan rate can increase above a maximum base scan rate by a factor of (AB)/(B-1), where A is the number of cycles of clocking performed and B is an integer corresponding to the predetermined row relationship.

Abstract: An electro-optical area array reconnaissance detector is disclosed which accomplishes forward motion compensation electronically and without moving parts. The array is made of photo-sensitive cells arranged in rows and columns, the columns being organized into one or more column groups. Charge packets collected in the cells representing scene information are transferred down the columns at the same rate as the image motion in the plane of the array. In a side oblique reconnaissance scenario, the columns may be organized into 16 column groups, each column group having its own charge transfer rate corresponding to the image motion rate in that column group.

Abstract: A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a release rate controlling membrane, and, a reservoir containing a medicinally active ingredient; the improvement in such system is based on the fact that said membrane is heat and pressure sealed to said backing without the use of a separate adhesive and is formed of a substantially linear block copolymer which is a reaction product of an amino functional polydiorganosiloxane which forms soft segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 50.degree. C. and 200.degree. C. said soft segments comprising from 60 to 90 percent by weight, based on the weight of said copolymer.

Abstract: A multi-layered multi-laminate sustained release device capable of releasing fragrances, colognes, and perfumes, at a controlled rate for a prolonged period of time and having a first layer of a pressure sensitive adhesive release liner for providing a protective peel strip for the device, a second layer of a silicone pressure sensitive adhesive for adhering the device to a substrate to which it is applied including human skin, a third layer of a fragrance oil impregnated matrix of a silicone material selected from the group consisting of silicone elastomers, silicone elastomers having adhesive characteristics, and elastomeric silicone pressure sensitive adhesives, and a fourth layer of a permeable facestock backing member on the surface of the device for controlling the rate of release of the fragrance oil from the impregnated matrix.

Abstract: A device for simultaneously tapping threads and performing the usual operations of a punch press is described in which the tapping device is attached to the upper and lower plates of a punch press. As the punch plates are brought toward and away from each other, gear trains and helically grooved lead screws change the up and down motion into rotating motion. The gear trains also change the speed of the rotating motion which is used to drive a thread tapping tool through the metal being formed in the punch press. If there is too much force opposing the tapping operation, an electrical contact in the device is opened and the punch press stopped before the tap or tapping device can be damaged.