Patents by Inventor William R. Roush

William R. Roush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS
    Publication number: 20180002343
    Abstract: The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 4, 2018
    Inventors: Thomas D. Bannister, William R. Roush, Jun Yong Choi, Reji Nair, Andy S. Tsai, Jitendra K. Mishra, John L. Cleveland
  • HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20170174619
    Abstract: The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.
    Type: Application
    Filed: March 30, 2015
    Publication date: June 22, 2017
    Inventors: Daiqing Liao, William R. Roush, Ryan L Stowe
  • Wee1 degradation inhibitors
    Patent number: 9493464
    Abstract: The invention provides compounds that inhibit the degradation of Wee1. The compounds of the present invention are generally N-((1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amines. Compounds of the invention can be used for treatment of malconditions in patients for which inhibition of Wee1 is medically indicated, for example cancer, Alzheimer's, neurological disorders, psychiatric disorders, or inflammation-related disorders.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: November 15, 2016
    Assignee: The Scripps Research Institute
    Inventors: William R. Roush, Ronald Rahaim, Mathieu Bibian
  • WEE1 DEGRADATION INHIBITORS
    Publication number: 20150274729
    Abstract: The invention provides compounds that inhibit the degradation of Weel. The compounds of the present invention are generally N-((1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amines. Compounds of the invention can be used for treatment of malconditions in patients for which inhibition of Weel is medically indicated, for example cancer, Alzheimer's, neurological disorders, psychiatric disorders, or inflammation-related disorders.
    Type: Application
    Filed: February 26, 2013
    Publication date: October 1, 2015
    Inventors: William R. Roush, Nagi Ayad, Ronald Rahaim, Scott P. Simanski, Mathieu Bibian