Patents by Inventor William R. Shanahan, Jr.

William R. Shanahan, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of STAT 6 expression
    Patent number: 8518904
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT 6. Methods of using these compounds for modulation of STAT 6 expression and for diagnosis and treatment of disease associated with expression of STAT 6 are provided.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: August 27, 2013
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: William R. Shanahan, Jr., Susan M. Freier, Kenneth W. Dobie
  • MODULATION OF STAT 6 EXPRESSION
    Publication number: 20120115932
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT 6. Methods of using these compounds for modulation of STAT 6 expression and for diagnosis and treatment of disease associated with expression of STAT 6 are provided.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 10, 2012
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: William R. Shanahan, JR., Susan M. Freier, Kenneth W. Dobie
  • MODULATION OF STAT 6 EXPRESSION
    Publication number: 20090292009
    Abstract: Compounds, compositions and methods are provided for modulating the expression of STAT 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT 6. Methods of using these compounds for modulation of STAT 6 expression and for diagnosis and treatment of disease associated with expression of STAT 6 are provided.
    Type: Application
    Filed: July 27, 2009
    Publication date: November 26, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: William R. Shanahan, JR., Susan M. Freier, Kenneth W. Dobie
  • Antisense oligonucleotide modulation of tumor necrosis factor-(&agr;) (TNF-&agr;) expression
    Patent number: 6228642
    Abstract: Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-&agr; (TNF-&agr;). Antisense oligonucleotides targeted to nucleic acids encoding TNF-&agr; are preferred. Methods of using these oligonucleotides for inhibition of TNF-&agr; expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-&agr; are provided.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: May 8, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Brenda F. Baker, C. Frank Bennett, Madeline M. Butler, William R. Shanahan, Jr.
  • Antisense oligonucleotide modulation of tumor necrosis factor-.alpha. (TNF-.alpha.) expression
    Patent number: 6080580
    Abstract: Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-.alpha. (TNF-.alpha.). Antisense oligonucleotides targeted to nucleic acids encoding TNF-.alpha. are preferred. Methods of using these oligonucleotides for inhibition of TNF-.alpha. expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-.alpha. are provided.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: June 27, 2000
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Brenda F. Baker, C. Frank Bennett, Madeline M. Butler, William R. Shanahan, Jr.