Patents by Inventor William R. Thelin

William R. Thelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monothiol mucolytic agents
    Patent number: 10968233
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: April 6, 2021
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Prodrugs of dithiol mucolytic agents
    Patent number: 10526283
    Abstract: Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 7, 2020
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Methods of treatment
    Patent number: 10335558
    Abstract: Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 2, 2019
    Assignee: PARION SCIENCES, INC.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • NOVEL MONOTHIOL MUCOLYTIC AGENTS
    Publication number: 20190031679
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Application
    Filed: September 5, 2018
    Publication date: January 31, 2019
    Inventors: Michael Ross JOHNSON, William R. THELIN
  • Monothiol mucolytic agents
    Patent number: 10106551
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 23, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, William R. Thelin
  • Dithiol mucolytic agents
    Patent number: 9963427
    Abstract: Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: May 8, 2018
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael R. Johnson, William R. Thelin, Ronald A. Aungst, Jr.
  • NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS
    Publication number: 20160318861
    Abstract: Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (Ia)-(Ib): where the structural variables are as defined herein.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 3, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William R. Thelin
  • NOVEL MONOTHIOL MUCOLYTIC AGENTS
    Publication number: 20160222023
    Abstract: Provided are mucolytic agents represented by formula (Ia)-(Id): where the structural variables R1, R2, R5 and R6 are as defined herein. Also provided are a variety of methods of treatment which take advantage of the mucolytic properties of the compounds represented by formula (Ia)-(Id).
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross JOHNSON, William R. THELIN
  • DITHIOL MUCOLYTIC AGENTS
    Publication number: 20160194278
    Abstract: Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
    Type: Application
    Filed: March 11, 2016
    Publication date: July 7, 2016
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, William R. THELIN, Ronald A. AUNGST, JR.
  • Dithiol mucolytic agents
    Patent number: 9346753
    Abstract: Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: May 24, 2016
    Assignee: PARION SCIENCES, INC.
    Inventors: Michael R. Johnson, William R. Thelin, Ronald A. Aungst, Jr.
  • NOVEL MUCOLYTIC AGENTS
    Publication number: 20150307530
    Abstract: Provided is a method of liquefying mucus from mucosal surfaces by administering compounds containing a phosphine group.
    Type: Application
    Filed: August 30, 2013
    Publication date: October 29, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. JOHNSON, William R. THELIN, Richard C. BOUCHER, Diane VILLALON, Jone L. BOYER
  • METHODS OF TREATMENT
    Publication number: 20150101597
    Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Application
    Filed: June 2, 2014
    Publication date: April 16, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Richard C. BOUCHER, Michael Ross JOHNSON, William R. THELIN, Brian BUTTON, Tomas NAVRATIL
  • DITHIOL MUCOLYTIC AGENTS
    Publication number: 20150056305
    Abstract: Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic, cohesive, or adhesive properties. Also provided are a variety of methods of treatment using these inventive mucolytic agents.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 26, 2015
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael R. Johnson, William R. Thelin, Ronald A. Aungst, JR.
  • Methods of treatment
    Patent number: 8778383
    Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: July 15, 2014
    Assignee: Parion Sciences, Inc.
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • METHODS OF TREATMENT
    Publication number: 20130074842
    Abstract: The present invention concerns methods, compositions and apparatus for administering active agents to the lungs of a subject.
    Type: Application
    Filed: June 7, 2012
    Publication date: March 28, 2013
    Inventors: Richard C. Boucher, Michael Ross Johnson, William R. Thelin, Brian Button, Tomas Navratil
  • MULTIPLE NEBULIZER SYSTEMS
    Publication number: 20100074881
    Abstract: A device for administering two or more therapeutic agents simultaneously, comprising two or more nebulizers and a single connector linking the nebulizers to a nebulizer mouthpiece. Also provided is a method of administering two or more therapeutic agents simultaneously, comprising administering the therapeutic agents simultaneously with the device of the present invention to a subject in need thereof.
    Type: Application
    Filed: July 13, 2009
    Publication date: March 25, 2010
    Applicant: PARION SCIENCES, Inc.
    Inventors: Richard C. BOUCHER, Michael R. Johnson, Keith A. Johnson, William R. Thelin