Abstract: A connecting device for connecting together tubular members is comprised of a resilient sheet member in the form of a coil having at least partially overlapping surfaces. The inner diameter of the sheet member coil is less than the outer diameter of the members to be joined. A layer of heat sensitive adhesive bonding material is provided over the inner surface and subsequently after the formation of the connection on the outer surface of the sheet member coil. The sheet member coil is expanded to a larger diameter against the resiliently inwardly directed force of the sheet member and held in the expanded condition by heat sensitive adhesive bonding material. The expanded larger diameter is of a sufficient diameter to receive the ends of the members to be joined.

Abstract: Viruses, particularly hepatitis viruses, in blood clotting enzyme compositions are inactivated with little enzyme activity loss by heating the compositions in the dry state. The novel products which result are therapeutically and diagnostically useful.

Abstract: Patients having a clotting factor defect can be successfully treated by the administration of a composition containing effective hemostatic amounts of factor VIIa. Preferably, the factor VIIa is substantially free of factors IXa and Xa. Procedures for preparing the above therapeutic compositions are also described.

Abstract: A device is provided for connecting together the ends of pipes or tubing or for repairing a fault in a pipe or tubing. The device is comprised of a resilient sheet member in the form of a coil having a layer of heat sensitive bonding material applied to the inner surface of the resilient sheet member. The resilient sheet member coil is formed to an inner diameter slightly less than the outer diameter of the pipe or tubing. In the case where the resilient sheet member is used as a connector, the resilient sheet member is sprung to a diameter larger than the outer diameter of the pipe or tubing and retained in this expanded form by a heat sensitive material which melts upon being heated to allow contraction of the connector. At the same time, the heat sensitive bonding material forms a tight bond to the two ends of the pipes or tubing to be connected.

Abstract: Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.

Abstract: Patients having a clotting factor defect can be successfully treated by the administration of a composition containing effective hemostatic amounts of factor VIIa. Preferably, the factor VIIa is substantially free of factors IXa and Xa. Procedures for preparing the above therapeutic compositions are also described. A method involving the activation of factor VII is set forth.

Abstract: A method and apparatus for repairing or relining an underground pipeline without having to excavate the pipe is enabled by attaching an expandable sealing unit to the end of a predetermined length of flexible tubing and feeding it through the pipeline. The flexible tubing is fed through the existing pipeline from a point beyond where the existing pipeline exits the earth, usually within the basement of a building. Once positioned in the desired location, the expandable sealing unit is expanded to form a tight seal at the desired location within the pipe by means of heating the expandable sealing unit by a heating unit connected to the source of energy through electrical conductors which pass through the flexible tubing.

Abstract: An improved animal caging system of the type having a plurality of hollow boxes suspended on flanges from a plurality of ducted shelves is provided. The ducting for the ventilation system is entirely enclosed and is formed integrally with the caging system rack. A sliding valve member mounted in each lid is biased to seal air openings to the cage upon removal from the rack, a protrusion contacting the rack to uncover the air openings upon cage insertion. Similar valves are optionally placed in the rack to maintain balanced airflow when a cage is removed. The system minimizes the possibility of cross-infection between occupants of different cages, and between people and cage occupants.

Abstract: A method and apparatus for repairing or relining an underground pipeline without having to excavate the pipe is enabled by attaching an expandable sealing unit to the end of a predetermined length of flexible tubing and feeding it through the pipeline. The flexible tubing is fed through the existing pipeline from a point beyond where the existing pipeline exits the earth, usually within the basement of a building. Once positioned in the desired location, the expandable sealing unit is expanded to form a tight seal at the desired location within the pipe by means of heating the expandable sealing unit by a heating unit connected to the source of energy through electrical conductors which pass through the flexible tubing.

Abstract: Patients having a clotting factor defect can be successfully treated by the administration of a composition containing effective hemostatic amounts of factor VIIa. Preferably, the factor VIIa is substantially free of factors IXa and Xa. Procedures for preparing the above therapeutic compositions are also described.

Abstract: A composition comprising about from 37 to 190 units of factor VII/ml and about from 25 to 80 units of factor VIIa/ml is administered to patients in the treatment of clotting factor inhibitors. The composition may include activated and unactivated clotting factors such as factors IX, IXa, Xa and X.

Abstract: An improved animal caging system of the type having a plurality of ventilated cages suspended on flanges from a plurality of shelves is provided. The ventilation duct system is entirely enclosed and forms an integral part of the caging system rack. Valves mounted in the air ducts or inlets on the cages, for controlling airflow to and from cages, and an arrangement for a tight fit between the cages and the ducts minimize the possibility of cross-infection between occupants of different cages, and between people and cage occupants. The valves are actuated upon insertion of the cage into the rack, whereby the cages and/or air ducts are sealed upon withdrawal. A negatively pressurized isolation box, adapted to interface with the cage rack, permits manipulation and servicing of cages and occupants, resulting in a contagion-safe total system.

Abstract: Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.

Abstract: This is an improved method for producing activated prothrombin complex concentrate which comprises controlling the degree of activation by determining the activation state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation of the starting material to arrive at a predetermined activation level.

Abstract: The rate of solubility of a freeze-dried solid composition containing therapeutic amounts of anti-hemophilic factor (AHF) is greatly increased by carrying out the solubilization in the presence of at least a critical threshold amount of a water soluble carbohydrate. The carbohydrate is incorporated into the AHF composition in sufficient quantity to provide at least 2 weight units of carbohydrate (expressed in grams) per 100 volume units of AHF solution (expressed in milliliters). This enhanced rate of solubility permits rapid treatment of hemophilic patients.

Abstract: Improved roof insulation for vehicles is provided. The insulation includes a layer of glass fibers held by a binder, which layer is flexible and compressible. A non-woven sheet is adhered to the lower surface of the fibrous layer and thereby improves the handleability of the layer and retains particulate material and especially fibers in the layer when being installed in a vehicle. The non-woven sheet also adds a degree of stiffness to the fibrous layer to prevent excessive drape thereof when being installed overhead, and yet the flexibility of the layer is retained. The non-woven sheet also protects the fibrous layer from tearing during installation and preferably can be dyed, which is particularly important when perforate headliners are employed therebelow. A non-woven porous sheet also can be employed on the upper surface of the fibrous layer which further improves the handleability and dimensional stability thereof, and protects the fibrous layer from damage.