Abstract: A method of treating neoplastic disease wherein a patient in need of such treatment is administered an effective amount of a radiation-activated cytotoxin prodrug (RACP) which has low toxicity, which is reducible by reducing agents generated by the radiolysis of water and which, upon reduction, releases a sufficient amount of a cytotoxic effector of sufficient cytotoxic potency to kill tumor cells. The tumor cells are irradiated with ionizing radiation to reduce the prodrug which is present at the locus of the tumor cells to release the cytotoxic effector.

Abstract: The invention provides nitroaniline derivatives represented by general formula (I) where the nitro group is substituted at any one of the available benzene positions 2-6; where R and A separately represent the groups NO.sub.2, CN, COOR.sup.1, CONR.sup.1 R.sup.2, CSNR.sup.1 R.sup.2 or SO.sub.2 NR.sup.1 R.sup.2 and A is substituted at any one of the available benzene positions 2-6; where B represents N(CH.sub.2 CH.sub.2 halogen).sub.2 or N(CH.sub.2 CH.sub.2 OSO.sub.2 R.sup.3).sub.2 substituted at any one of the available benzene positions; and where R.sup.1, R.sup.2 and R.sup.3 separately represent H, or lower alkyl optionally substituted with hydroxyl, ether, carboxy or amino functions, including cyclic structures, or R.sup.1 and R.sup.2 together with the nitrogen form a heterocyclic structure, and pharmaceutical preparations containing them. These compounds have activity as hypoxia-selective cytotoxins, reductively-activated prodrugs for cytotoxins, hypoxic cell radiosensitisers, and anticancer agents.

Abstract: New cobalt complexes of nitrogen mustard alkylating agents which have been found to have hypoxia-selective antitumor properties and are thereby useful antitumor agents are described.

Abstract: An electro-mechanical lock which includes a housing having right and left side cavities in which a latch block may be selectively mounted to cooperatively retain a tongue extending from a door or gate which slides or swings from either the left or right side. The latch block includes a pivotable "J" latch which is engageable within a slot in the tongue extending from a gate or door to be locked as the tongue engages the "J" latch as the gate or door is closed. A latch retainer is operable to secure the latch in an engaged position with the tongue and is retractable by a solenoid or mechanical element controlled by a key operated cylinder to release the "J" latch and allow opening of the gate or door.

Abstract: A digital control system for controlling the flow of traffic in selected directions in response to digital signals transmitted from a common transmitting control unit to multiple separate receiving traffic control units respectively associated with each controlled direction. The transmitting unit includes a transmitter and digital command code generator operative when actuated to transmit a character in the form of a digital signal specific for one of the receiving units. Each receiving unit includes traffic control indicators operative in different modes of display indications visible to traffic flowing in the direction to be controlled by that unit.

Abstract: A transceiver includes a keyboard having a plurality of manually actuable keys for selecting operating modes and channels for operating thereon. A first digital processor has inputs coupled to the keyboard for receiving logic signals therefrom of a first format identifying the keys which are manually actuated. In response thereto, the first digital processor generates bit serial messages of a second format indicating the manually chosen operating mode and channel. A second digital processor has inputs coupled to receive the bit serial messages. In response thereto, the second digital processor generates a plurality of micro commands. A clocking signal generator circuit and switching circuit are coupled to receive the micro commands to control the transceiver.

Abstract: A transceiver has digital transmitting capability. The transceiver includes an antenna having an input for transmitting signals applied thereto. Signal generating means generate first and second signals having first and second frequencies, and transmission means selectively couple the first and second signals to the antenna input in response to first and second micro commands respectively. A processor receives manually chosen messages for transmission comprised of a series of binary encoded symbols. In response thereto, the processor sequentially generates for a predetermined time interval the first micro command for each one bit and the second micro command for each zero bit to be transmitted.

Abstract: A system for determining the position of a ship in relation to predetermined positions on the ocean floor is disclosed. A plurality of first acoustic addressable transponders and a plurality of second acoustic addressable transponders are respectively located at first and second sets of predetermined positions on the ocean floor. Each of the acoustic transponders transmits an acoustic ranging response and identification signal in response to receipt of an acoustic ranging interrogation signal. First and second buoy communications systems are located on first and second buoys respectively moored to the ocean floor in the vicinity of the first and second pluralities of acoustic transponders.