Abstract: A computer-implemented method includes determining a set of related medical activities based on received medical evidence, providing a set of tools, each tool corresponding to at least one of the related medical activities in the set, identifying a set of content blocks in each tool in the set of tools, including identifying content blocks that can be common to at least two tools, determining a medical condition of a patient, and selecting a first tool from the set of tools based on the medical condition.

Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. There is also provided a method of inducing a CD4+ T-cell response against a target antigen, by administering a composition comprising a source of one or more CD4+ T cell epitopes of the target antigen wherein the source of CD4+ epitopes is a non-replicating or replication impaired recombinant poxvirus vector. A method of inducing a combined CD4+ and CD8+ T cell response against a target antigen is also described herein.