Patents by Inventor William Ripka

William Ripka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hedgehog inhibitors
    Patent number: 9174949
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: November 3, 2015
    Assignee: SELEXAGEN THERAPEUTICS, INC.
    Inventors: Jean-Michel Vernier, John May, Patrick O'Connor, William Ripka, Anthony Pinkerton, Pierre-Yves Bounaud, Stephanie Hopkins
  • Antagonist of smoothened
    Patent number: 8486936
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: July 16, 2013
    Assignee: AllaChem, LLC
    Inventors: Alexander Khvat, Sergey Tkachenko, Ilya Okun, Borys Rogovoy, Nikolay Savchuk, John May, Patrick O'Connor, William Ripka, Jean-Michel Vernier, David Matthews
  • RAF KINASE INHIBITORS
    Publication number: 20130040983
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
    Type: Application
    Filed: January 7, 2011
    Publication date: February 14, 2013
    Inventors: Jean-Michel Vernier, Patrick O'Connor, William Ripka, David Matthews, Anthony Pinkerton, Pierre-Yves Bounaud, Stephanie Hopkins
  • HEDGEHOG INHIBITORS
    Publication number: 20130012513
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
    Type: Application
    Filed: January 6, 2011
    Publication date: January 10, 2013
    Inventors: Jean-Michel Vernier, John May, Patrick O'Connor, William Ripka, Anthony Pinkerton, Pierre-Yves Bounaud, Stephanie Hopkins
  • ANTAGONIST OF SMOOTHENED
    Publication number: 20110098291
    Abstract: Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
    Type: Application
    Filed: May 4, 2010
    Publication date: April 28, 2011
    Applicant: Alla Chem Inc.
    Inventors: Alexander KHVAT, Sergey TKACHENKO, Ilya OKUN, Borys V. ROGOVOY, Nikolay SAVCHUK, John MAY, Patrick O'CONNOR, William RIPKA, Jean-Michel VERNIER, David MATTHEWS
  • HETEROCYCLIC BORONIC ACID COMPOUNDS
    Publication number: 20070185061
    Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CRiRii, R1, R2, R3, R4 and R5 are as described herein.
    Type: Application
    Filed: November 6, 2006
    Publication date: August 9, 2007
    Inventors: David Campbell, David Winn, Juan Betancort, Kevin Shreder, Yi Hu, Bei Li, Melissa Wong, Lifu Ma, William Ripka, Min Wu
  • Compounds for treatment of neurodegenerative diseases
    Publication number: 20060004041
    Abstract: The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.
    Type: Application
    Filed: May 3, 2005
    Publication date: January 5, 2006
    Inventors: Christopher Cummings, David Lowe, William Ripka