Abstract: The present disclosure provides for the treatment of cardiac diseases and disorders using in vitro-differentiated cardiomyocytes. Such methods can take advantage of both autologous and allogeneic pluripotent stem cells.

Abstract: A multi-modal diagnostic test reading apparatus, comprising: a diagnostic test assembly receiving component; at least one image sensor; a plurality of light sources having respective different spectral properties; and a controller; wherein the controller is configured to: (i) control operation of the light sources and the at least one image sensor to acquire a plurality of images, each of the acquired images representing at least a corresponding portion of the diagnostic test assembly as illuminated by a corresponding one of the light sources; and (ii) process the acquired images to determine a diagnostic test result of the diagnostic test, the diagnostic test result being dependent upon the processed images representing illumination by respective ones of the light sources having respective different spectral properties.

Abstract: The present disclosure is directed to systems and methods useful for the construction and operation of a Modular Integrated Gas High-Temperature Reactor (MIGHTR). The MIGHTR includes a reactor core assembly disposed at least partially within a core baffle within a first high-pressure shell portion, a thermal transfer assembly disposed at least partially within a flow separation barrel within a second high-pressure shell portion. The longitudinal axes of the first high-pressure shell portion and the second high-pressure shell portion may be collinear. The reactor core assembly may be accessed horizontally for service, maintenance, and refueling. The core baffle may be flexibly displaceably coupled to the flow separation barrel. Coolant gas flows through the reactor core assembly and into the thermal transfer assembly where the temperature of the coolant gas is reduced. A plurality of coolant gas circulators circulate the cooled coolant gas from the thermal transfer assembly to the reactor core assembly.

Abstract: Described herein are methods and compositions for reducing or preventing arrhythmias associated with or caused by transplantation of cardiomyocytes to cardiac tissue. In particular embodiments, the pre-treatment of in vitro-differentiated cardiomyocytes with amiodarone before administration to cardiac tissue for engraftment reduces or prevents engraftment arrhythmias, and/or reduces the need for adjunctive anti-arrhythmia drugs after cell administration.

Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a

Abstract: Described herein are methods and compositions related to treating and preventing an engraftment arrhythmia with an effective amount of amiodarone and ivabradine. Also described herein is a method of cardiomyocyte transplant, the method comprises: dministering in vitro-differentiated cardiomyocytes to cardiac tissue of a subject in need thereof; and administering to the subject an amount of amiodarone and an amount of ivabradine effective to reduce engraftment arrhythmia in the subject.

Abstract: Described herein are methods and compositions related to methods of improving survival and engraftment of human cells differentiated in vitro, and uses thereof.

Abstract: The present disclosure is directed to systems and methods useful for the construction and operation of a Modular Integrated Gas High-Temperature Reactor (MIGHTR). The MIGHTR includes a reactor core assembly disposed at least partially within a core baffle within a first high-pressure shell portion, a thermal transfer assembly disposed at least partially within a flow separation barrel within a second high-pressure shell portion. The longitudinal axes of the first high-pressure shell portion and the second high-pressure shell portion may be collinear. The reactor core assembly may be accessed horizontally for service, maintenance, and refueling. The core baffle may be flexibly displaceably coupled to the flow separation barrel. Coolant gas flows through the reactor core assembly and into the thermal transfer assembly where the temperature of the coolant gas is reduced. A plurality of coolant gas circulators circulate the cooled coolant gas from the thermal transfer assembly to the reactor core assembly.

Abstract: An apparatus for cooling an engine component such as a turbine engine airfoil, including a wall bounding an interior extending axially between a leading edge and a trailing edge and radially between a root and a tip. A cooling circuit it located within the interior of the airfoil can include a flow enhancer permitting a volume of fluid, such as air, to pass around the flow enhancer.

Abstract: An apparatus and method for cooling an engine component, such as an airfoil, for a turbine engine including an outer wall separating a cooling fluid flow from a hot fluid flow. A cooling circuit including a cooling passage having opposing sidewalls can be provided in the engine component. At least one turbulator can be provided between the opposing sidewalls, and can include a conduit having an inlet and an outlet passing through the at least one turbulator.

Abstract: Thermal degradation monitoring systems and methods determine at least one operating parameter of equipment that defines prior usage of the equipment, determine at least one thermal characteristic of the equipment using one or more thermal imaging cameras, determine whether both the at least one operating parameter and the at least one thermal characteristic indicate thermal degradation of the equipment, and implement one or more remedial actions on the equipment to change a state of the equipment in response to determining that the at least one operating parameter and the at least one thermal characteristic indicate thermal degradation of the equipment.

Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a

Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a

Abstract: An apparatus and method for cooling an engine component, such as an airfoil, for a turbine engine including an outer wall separating a cooling fluid flow from a hot fluid flow. A cooling circuit including a cooling passage having opposing sidewalls can be provided in the engine component. At least one turbulator can be provided between the opposing sidewalls, and can include a conduit having an inlet and an outlet passing through the at least one turbulator.

Abstract: Thermal degradation monitoring systems and methods determine at least one operating parameter of equipment that defines prior usage of the equipment, determine at least one thermal characteristic of the equipment using one or more thermal imaging cameras, determine whether both the at least one operating parameter and the at least one thermal characteristic indicate thermal degradation of the equipment, and implement one or more remedial actions on the equipment to change a state of the equipment in response to determining that the at least one operating parameter and the at least one thermal characteristic indicate thermal degradation of the equipment.

Abstract: An apparatus for cooling an engine component such as a turbine engine airfoil, including a wall bounding an interior extending axially between a leading edge and a trailing edge and radially between a root and a tip. A cooling circuit it located within the interior of the airfoil can include a flow enhancer permitting a volume of fluid, such as air, to pass around the flow enhancer.

Abstract: Techniques are described for identifying book title sets. The techniques may include a first-pass comparison with other books to identify other candidate title sets. A second-pass comparison may then be performed with respect to the candidate title sets. The first-pass comparison may be based on book metadata such as titles and authorship. The second-pass comparison may include a more comprehensive content comparison, such as comparing the body text of the books.

Abstract: A nucleic acid amplification and detection apparatus, including: a support configured to receive a plurality of reaction vessels containing respective samples of one or more nucleic acids to be amplified, the support being rotatable about an axis of rotation and the reaction vessels being received in the support at respective receiving locations distributed about the axis of rotation; a temperature control component thermally coupled to the support and configured to control the temperature of the support in order to amplify the nucleic acids contained in the reaction vessels while received in the support; one or more measurement components configured to measure one or more characteristics of the nucleic acids within the reaction vessels at respective measurement locations distributed about the axis of rotation; an actuator coupled to the support and configured to rotate the support about the axis of rotation; and a sample position controller coupled to the actuator and being configured to rotate the support a

Abstract: The invention concerns a portable device for reading a fluorescent-labelled, membrane based assay, to detect the presence of an analyte in a sample. The portable device comprises a light sealed housing which includes a receiving member to receive a membrane based assay. The light sealed housing comprises a first light source for illuminating a first portion of the membrane with light, a first photodetector, a light guide and a microprocessor. The first photodetector is operable to detect fluoresced light emitted by an excited fluorescent label captured by a reagent laid down in the first portion of the membrane and to measure an intensity of the fluoresced light. The light guide guides illuminated light from the first light source to the first portion of the membrane and guides fluoresced light emitted by the excited fluorescent label to the first photodetector. The microprocessor is operable to process the measured intensity of the fluoresced light to determine whether the analyte is present.

Abstract: A method for dispensing blended fertilizer to a customer at a dispensing site, which may be remote and unmanned. The fertilizer dealer enters the blend of standard fertilizer ingredients required to provide the customer's desired nutrients into a database identified with the customer. The customer identifies himself to a dispensing site based computer which recognizes the blend and operates a blending and dispensing apparatus to dispense the desired quantity of blended fertilizer to the customer. A plurality of blends may be available to the customer.