Patents by Inventor William Robb MACLELLAN

William Robb MACLELLAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CARDIOMYOCYTE TRANSPLANTATION
    Publication number: 20240122990
    Abstract: The present disclosure provides for the treatment of cardiac diseases and disorders using in vitro-differentiated cardiomyocytes. Such methods can take advantage of both autologous and allogeneic pluripotent stem cells.
    Type: Application
    Filed: February 22, 2022
    Publication date: April 18, 2024
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. MURRY, William Robb MACLELLAN, Robert Scott THIES, Kenta NAKAMURA, Daisy Sue NAKAMURA, Lauren E. NEIDIG
  • PRE-TREATING CARDIOMYOCYTES WITH ANTI-ARRHYTHMIC DRUGS TO REDUCE ENGRAFTMENT ARRHYTHMIA
    Publication number: 20230250393
    Abstract: Described herein are methods and compositions for reducing or preventing arrhythmias associated with or caused by transplantation of cardiomyocytes to cardiac tissue. In particular embodiments, the pre-treatment of in vitro-differentiated cardiomyocytes with amiodarone before administration to cardiac tissue for engraftment reduces or prevents engraftment arrhythmias, and/or reduces the need for adjunctive anti-arrhythmia drugs after cell administration.
    Type: Application
    Filed: January 20, 2023
    Publication date: August 10, 2023
    Applicant: University of Washington
    Inventors: Charles E. MURRY, William Robb MACLELLAN, Robert Scott THIES, Kenta NAKAMURA
  • METHODS OF TREATING AND PREVENTING ENGRAFTMENT ARRHYTHMIAS
    Publication number: 20230077983
    Abstract: Described herein are methods and compositions related to treating and preventing an engraftment arrhythmia with an effective amount of amiodarone and ivabradine. Also described herein is a method of cardiomyocyte transplant, the method comprises: dministering in vitro-differentiated cardiomyocytes to cardiac tissue of a subject in need thereof; and administering to the subject an amount of amiodarone and an amount of ivabradine effective to reduce engraftment arrhythmia in the subject.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 16, 2023
    Applicants: UNIVERSITY OF WASHINGTON, VANDERBILT UNIVERSITY
    Inventors: Robert Scott THIES, William Robb MACLELLAN, Kenta NAKAMURA, Charles E. MURRY, Bjorn KNOLLMANN
  • IMPROVED SURVIVAL OF HUMAN CELLS DIFFERENTIATED IN VITRO BY PRPF31 GENE EXPRESSION KNOCKDOWN
    Publication number: 20220152278
    Abstract: Described herein are methods and compositions related to methods of improving survival and engraftment of human cells differentiated in vitro, and uses thereof.
    Type: Application
    Filed: March 13, 2020
    Publication date: May 19, 2022
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. MURRY, Sarah DUPRAS, John LAMACCHIA, James FUGATE, William Robb MACLELLAN, Lil PABON, Jr., Scott THIES, Hiroshi TSUCHIDA, Stephanie A. TUCK