Patents by Inventor William Robert SPREEN

William Robert SPREEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM TO CALCULATE HUMAN ORAL BIOAVAILABILITY
    Publication number: 20250123273
    Abstract: The invention relates to methods and systems for the co-culture of primary liver cells and primary intestinal cells. In particular, the invention has application in estimating bioavailability.
    Type: Application
    Filed: October 13, 2023
    Publication date: April 17, 2025
    Inventors: Yassen Abbas, Hailey Sze, Tomasz Kostrzewski, William Robert Thelin, Elizabeth Mansfield Boazak, Ashley Ann Spreen
  • METHOD OF ACHIEVING HIV VIRAL REMISSION USING LONG-ACTING ANTIRETROVIRAL AGENTS
    Publication number: 20230226050
    Abstract: A method of achieving HIV viral remission in a patient in need thereof, comprising the steps of: after exposure of the patient to the HIV virus, administering an early antiretroviral therapy (eART) of therapeutically effective amounts of cabotegravir and rilpivirine long-acting antiretrovirals, and after eART suppression of the virus, discontinuing said early antiretroviral therapy.
    Type: Application
    Filed: June 30, 2021
    Publication date: July 20, 2023
    Inventors: Michele B. DALY, Jose Gerardo GARCIA LERMA, Walid M. HENEINE, William Robert SPREEN, Peter Evan Owen WILLIAMS
  • Method for treating HIV with Cabotegravir and Rilpivirine
    Publication number: 20220347174
    Abstract: Invented are methods for treating HIV in a human in need thereof which comprises the administration of a therapeutically effective amount of a combination of cabotegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof, to such human.
    Type: Application
    Filed: October 1, 2020
    Publication date: November 3, 2022
    Inventors: Herta Maria Ludovica CRAUWELS, Susan L. FORD, David Andrew MARGOLIS, Stefaan Louis F. ROSSENU, William Robert SPREEN, Rodica Mihaela VAN SOLINGEN-RISTEA, Peter Evan Owen WILLIAMS