Patents by Inventor William Rom

William Rom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190004051
    Abstract: An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 3, 2019
    Inventors: Joshua Labaer, Ji Qiu, Jie Wang, Garrick Wallstrom, Jin Park, William Rom, Harvey Pass
  • Patent number: 7741298
    Abstract: The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis using agents that inhibit the sonic hedgehog and GLI signaling pathway, including agents that inhibit GLI expression, synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of cancer. Methods of treating cancer, including glioblastomas, medulloblastomas, basal cell carcinomas, prostate cancer and small cell and non-small cell lung cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: June 22, 2010
    Assignee: New York University
    Inventors: Ariel Ruiz i Altaba, Pilar Sanchez, William Rom, Kam-Meng Tchou Wong
  • Publication number: 20090204334
    Abstract: Disclosed are protein biomarkers and their use in diagnosing lung cancer or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of lung cancer that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers to make a probable diagnosis of lung cancer. In certain aspects of the invention, the methods include use of a decision tree analysis. Various computer readable media and their use according to the invention are also disclosed.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 13, 2009
    Applicant: EASTERN VIRGINIA MEDICAL SCHOOL
    Inventors: O. John Semmes, Lisa H. Cazares, William Rom
  • Publication number: 20090123422
    Abstract: A method of treating idiophathic pulmonary fibrosis (IPF), comprising administering aerosolized interferon-? in a therapeutically effective amount to achieve improved or ameliorated symptoms of IPF.
    Type: Application
    Filed: January 13, 2009
    Publication date: May 14, 2009
    Inventors: Rany Condos, William Rom, Gerald Smaldone
  • Patent number: 6964761
    Abstract: A method of treating idiophathic pulmonary fibrosis (IPF), comprising administering aerosolized interferon-? in a therapeutically effective amount to achieve improved or ameliorated symptoms of IPF.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: November 15, 2005
    Assignees: New York University, The Research Foundation of the State University of New York
    Inventors: Rany Condos, William Rom, Gerald Smaldone
  • Publication number: 20050220763
    Abstract: A method of treating idiophathic pulmonary fibrosis (IPF), comprising administering aerosolized interferon-? in a therapeutically effective amount to achieve improved or ameliorated symptoms of IPF.
    Type: Application
    Filed: May 25, 2005
    Publication date: October 6, 2005
    Inventors: Rany Condos, William Rom, Gerald Smaldone
  • Publication number: 20050112707
    Abstract: The present invention relates to compounds, small interfering RNAs and compositions and methods of inhibiting tumorigenesis using agents that inhibit the sonic hedgehog and GLI signaling pathway, including agents that inhibit GLI expression, synthesis and/or function. The present invention also relates to particular biomarkers that can be used in the diagnosis and prognosis of cancer. Methods of treating cancer, including glioblastomas, medulloblastomas, basal cell carcinomas, prostate cancer and small cell and non-small cell lung cancer are also provided using small organic compounds, siRNAs and blocking antibodies that inhibit or block the SHH/GLI pathway.
    Type: Application
    Filed: August 31, 2004
    Publication date: May 26, 2005
    Inventors: Ariel Altaba, Pilar Sanchez, William Rom, Kam-Meng Wong