Abstract: The invention is a reorganization system having a reorganization application, a database management system, and one or more database files. The reorganization application communicates with the database management system and the one or more database files to reorganize an object, such as, for example, a table or index, while providing one or more clients substantially continuous access to the object. The reorganization application employs one or more trigger locks to synchronize the data in an original table and a reorganized table. The one or more trigger locks block select data modification operations while allowing one or more read-only operations and structural modification operations.

Abstract: The invention is a reorganization system having a reorganization application, a database management system, and one or more database files. The reorganization application communicates with the database management system and the one or more database files to reorganize an object, such as, for example, a table or index, while providing one or more clients substantially continuous access to the object. The reorganization application employs one or more trigger locks to synchronize the data in an original table and a reorganized table. The one or more trigger locks block select data modification operations while allowing one or more read-only operations and structural modification operations.

Abstract: The invention is a reorganization system having a reorganization application, a database management system, and one or more database files. The reorganization application communicates with the database management system and the one or more database files to reorganize an object, such as, for example, a table or index, while providing one or more clients substantially continuous access to the object. The reorganization application employs one or more trigger locks to synchronize the data in an original table and a reorganized table. The one or more trigger locks block select data modification operations while allowing one or more read-only operations and structural modification operations.

Abstract: Aspects of embodiments of the present disclosure include a highly available database cluster employing replication between two or more data files. The cluster also can maintain a connection with potentially geographically remote client application programs, including non-fault tolerant application programs, even in the event of one of the database management systems (DBMS) of the cluster becoming unavailable.

Abstract: A method of fabrication of a rocket engine nozzle assembly using pressure brazing generally includes initially assembling a rocket engine nozzle liner into a rocket engine nozzle jacket for a rocket engine nozzle assembly. The rocket engine nozzle assembly may then be sealed. Prior to pressure brazing the rocket engine nozzle assembly, pressure brazing parameters may be determined. The pressure brazing may be performed with the determined pressure brazing parameters to complete the fabrication of the rocket engine nozzle. The rocket engine nozzle assembly may include a rocket engine nozzle jacket and a rocket engine nozzle liner having a plurality of channels, with the space between each channel defining a land, and the rocket engine nozzle liner having at least a pair of endlands disposed at each end thereof. The rocket engine nozzle liner is bonded to the rocket engine nozzle jacket by the endlands being bonded to the nozzle jacket and the lands being pressure brazed to the nozzle jacket.

Abstract: The invention is a reorganization system having a reorganization application, a database management system, and one or more database files. The reorganization application communicates with the database management system and the one or more database files to reorganize an object, such as, for example, a table or index, while providing one or more clients substantially continuous access to the object. The reorganization application employs one or more trigger locks to synchronize the data in an original table and a reorganized table. The one or more trigger locks block select data modification operations while allowing one or more read-only operations and structural modification operations.

Abstract: The invention is directed to intermediates useful for making indazole compounds that modulate and/or inhibit cell proliferation.

Abstract: The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Abstract: A dental flossing tool and dispenser includes a case with an enclosed chamber divided by a partition wall into floss spool and take up reel compartments. A hub mounts a floss spool for rotation within the floss spool compartment. A take up reel is rotatable within the take up reel compartment. A rotator on the take up reel, is at least partially disposed outward of the take up reel compartment. Floss in-feed and out-feed openings in the case communicate with the respective compartments. A length of floss extends through the floss out-feed opening and back into the take up reel compartment through the floss in-feed opening, thereby forming a bight in the floss outward of the case. A unidirectional rotation limiter allows rotation of the take up reel to take up the length of floss but inhibits pay out of floss.

Abstract: Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Abstract: Aminothiazole compounds with N-containing cycloalkyl at the 2-amino position which are represented by the Formula (I), or a pharmaceutically acceptable prodrug of said compound, pharmaceutically active metabolite or pharmaceutically acceptable salt of said compound, or metabolite thereof, modulate and/or inhibit the cell proliferation and activity of protein kinases. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.

Abstract: 3,5 disubstituted indazole compounds with substituted nitrogen bearing 5-membered heterocycles in the 3-position that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.