Abstract: The present invention provides a method of promoting bone growth in a subject in need thereof, by administering to the subject a therapeutically effective amount of a compound of Formula I. The compounds include the salts, hydrates and isomers thereof. The present invention also provides methods for the treatment of renal disease and cancer.

Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R1 and R2 is H, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkoxy, —OR4, —NR4R5, —SR4, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4 and R5 is H or C1-6 alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.

Abstract: The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include the following: wherein R1 and R2 are each H or C1-6 alkyl. X is C1-6 alkylene. R3 is H, —OR4, —OC(O)R4, —OC(O)NR4R5, —OC(O)OR4, —OP(O)(OR4)2 or —OC(O)(CH2)2C(O)OH. R4 and R5 are each independently H or C1-20 alkyl. The compounds also include salts, hydrates and isomers of the compounds.

Abstract: A composition and method for treating a skin problem, particularly atopic dermatitis, the composition comprising an antiseptic dye, preferably gentian violet, in a vehicle effective for topical administration.

Abstract: Methods and apparatus including a virtual machine and a compression network platform are provided especially for improving the application of compression algorithms and unique identifiers for algorithms, bytecode and HTTP common phrases of HTTP messages utilized to advantage in wireless networks. In particular, a given virtual machine need only identify to a receiving virtual machine the unique identifier for one of an algorithm, a static dictionary or a hash for decompressing a received data signal. Universal decompressor virtual machines may receive uploaded compression algorithms, bytecode identifiers or static dictionary identifiers and the like from proxy call session control functions of a wireless network, the compressing machine or a compression network platform resource which in one embodiment may comprise an IANA database. The methods and apparatus may find particular application in improving the efficiency of presence/group list management.

Abstract: Methods and apparatus including a virtual machine and a compression network platform are provided especially for improving the application of compression algorithms and unique identifiers for bytecode and bytecode packages including associated static dictionaries utilized to advantage in wireless networks. In particular, a given virtual machine need only identify to a receiving virtual machine the unique package identifier for one or more of an algorithm, a static dictionary or a hash for decompressing a received data signal. The receiving virtual machine may advertise what it has locally available to it so that no uploading is necessary. The actuation of bytecode by identifier may be requested at a given destination within the parameters set by RFC 3320.

Abstract: A method of treating a patient having a condition selected from the group including hypertension, hypertensive crises, angina pectoris, chronic arthritis, erectile dysfunction, cerebral ischemia and chronic skin ulcers comprising the step of administering to the patient a therapeutically effective amount or dose, or series of amounts or doses, of ultraviolet light.

Abstract: The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.

Abstract: A method and composition for stimulating skin function to prevent and reverse the effects of photoaging, without removal of the protective stratum corneum. The composition of the invention is a mixture of coarse pumice and an aqueous surfactant emulsion.

Abstract: A method used in wireless communications for displaying an icon on a wireless communications device indicating that a calling party is a subscriber of a same wireless communications service provider of a called party. A terminating mobile station switching center (MSC) flags a routing number port associated with a routing number and returns the routing number to an originating MSC when it determines that a request for the routing number is sent from a home locator register (HLR) of the called party's wireless communications service provider and the calling party is also a subscriber of the called party's wireless communications service provider. When receiving an incoming call, the terminating MSC inspects whether the incoming call is to be sent through a flagged routing number port. If so, the terminating MSC generates a SETUP message with an instructions to display the icon.

Abstract: A method used in wireless communications for displaying an icon on a wireless communications device indicating that a calling party is a subscriber of a same wireless communications service provider of a called party. A terminating mobile station switching center (MSC) flags a routing number port associated with a routing number and returns the routing number to an originating MSC when it determines that a request for the routing number is sent from a home locator register (HLR) of the called party's wireless communications service provider and the calling party is also a subscriber of the called party's wireless communications service provider. When receiving an incoming call, the terminating MSC inspects whether the incoming call is to be sent through a flagged routing number port. If so, the terminating MSC generates a SETUP message with an instructions to display the icon.

Abstract: A method of treating a patient having a condition selected from the group including hypertension, hypertensive crises, angina pectoris, chronic arthritis, erectile dysfunction, cerebral ischemia and chronic skin ulcers comprising the step of administering to the patient a therapeutically effective amount or dose, or series of amounts or doses, of ultraviolet light.

Abstract: A composition and method for treating soft nails, particularly soft fingernails, the composition including bisphosphonate, preferably alendronate sodium, in a vehicle effective for topical administration.

Abstract: The present invention provides a method of detecting HCV genotype 1 (HCV-1) in a sample which is based on the finding that the 5? non-coding region (NCR) of the HCV genome is conserved between HCV-1 quasi-species but not between other HCV subgroups. The method comprises subjecting the sample to an amplification reaction using at least one primer which anneals specifically to the 5? noncoding region (5? NCR) of the HCV-1 genome, and detecting the product of the amplification reaction. Kits and primers suitable for carrying out the method are also provided.

Abstract: An intraoperative image-guidance system for real-time visualization of non-anatomic bone properties utilizing hardware, software and display means to determine such properties as bone density or obstructions to surgical instrument movement. Real-time determination of such properties enhances the surgical procedure by ensuring desirable screw placement optimized for pullout strength or using SPECT to determine minimally-invasive surgical paths.

Abstract: A composition and method for treating soft nails, particularly soft fingernails, the composition including bisphosphonate, preferably alendronate sodium, in a vehicle effective for topical administration.

Abstract: Methods for diagnosing a systemic or autoimmune disorder and methods for treating the same by inducing the production of or otherwise providing an autoantibody that recognizes a skin basement membrane component.

Abstract: A skin biopsy system covers all aspects of the biopsy procedure from initial incision to final closure. The system includes a flexible closure consisting of 4 elongated rigid members interconnected by flexible hinges. The opening within the closure is initially diamond-shaped, approximating an ellipse, which is then deformed or pinched to a narrow linear opening when the wound is closed. Included with the system is a knife which interacts with the closure to yield a guided incision of constant depth. The path of the knife is guided by interference between the blade and the inside faces of the closure while the depth is limited by interference of the handle proximal the blade and the top faces of the closure.

Abstract: Pharmaceutical compositions and methods for use in the treatment of psoriasis, having isopropyl myristate as a first active ingredient and a different anti-psoriatic agent as a second active ingredient; preferably they are combined in the same pharmaceutical composition.

Abstract: A pharmaceutical composition for use in the treatment of psoriasis, having isopropyl myristate as its only active ingredient.