Abstract: Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

Abstract: The preparation of antigens and their selective antibodies for antipyrine therefrom as well as an immunoassay for antipyrine using said antibodies is described. Such radioimmunoassay can be utilized to determine an individual's antipyrine half-life which has been correlated with the genetically controlled level of benzo[a]pyrene hydroxylase induction. The latter measurement has been associated with risk to bronchogenic carcinoma. Thus determination of the antipyrine half-life by means of the instant radioimmunoassay can be used as a screening test for identifying individuals at special risk to lung cancer.