Patents by Inventor William Rowe

William Rowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210251978
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-diethylethyl)-5-hydroxyphenyl]-1,4-dihydro-1-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Application
    Filed: December 5, 2019
    Publication date: August 19, 2021
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • Publication number: 20210023070
    Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
    Type: Application
    Filed: April 7, 2020
    Publication date: January 28, 2021
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: William Rowe, Patricia Hurter, Christopher Young, Kirk Dinehart, Marinus Jacobus Verwijs, Kirk Overhoff, Peter D.J. Grootenhuis, Martyn Botfield, Alfredo Grossi
  • Publication number: 20200352930
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-diethylethyl)-5-hydroxyphenyl]-1,4-dihydro-1-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Application
    Filed: December 5, 2019
    Publication date: November 12, 2020
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • Publication number: 20200262815
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Application
    Filed: November 25, 2019
    Publication date: August 20, 2020
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • Publication number: 20200209236
    Abstract: The disclosed embodiments concern methods, devices, and systems for identifying candidate biomarkers useful for the diagnosis, prognosis, monitoring and screening and/or as targets for the treatment of diseases and conditions in subjects, in particular autoimmune and infectious diseases. The identification of candidate biomarkers is predicated on identifying discriminating peptides present on a peptide array, which can distinguish samples from different subjects having different health conditions by the binding patterns of antibodies present in the samples.
    Type: Application
    Filed: November 10, 2017
    Publication date: July 2, 2020
    Inventors: Robert William GERWIEN, Theodore Michael TARASOW, Jonathan Scott MELNICK, Kathryn Frances SYKES, Michael William ROWE
  • Patent number: 10646481
    Abstract: The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: May 12, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: William Rowe, Patricia Hurter, Christopher Young, Kirk Dinehart, Marinus Jacobus Verwijs, Kirk Overhoff, Peter D. J. Grootenhuis, Martyn Botfield, Alfredo Grossi
  • Publication number: 20200064345
    Abstract: The disclosed embodiments concern non-invasive methods, and apparatus, and systems for identifying infections. The methods are predicated on identifying discriminating peptides present on a peptide array, which are differentially bound by the different mixtures of antibodies present in samples from subjects consequent to an infection relative to binding of mixtures of antibodies present in reference subjects.
    Type: Application
    Filed: February 22, 2018
    Publication date: February 27, 2020
    Inventors: Kathryn Frances SYKES, Robert William GERWIEN, Jonathan Scott MELNICK, Michael William ROWE, Theodore Michael TARASOW
  • Publication number: 20200038389
    Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.
    Type: Application
    Filed: July 15, 2019
    Publication date: February 6, 2020
    Applicant: Gilead Sciences, Inc.
    Inventors: Laura Elizabeth Bauer, Anna Chiu, Eric M. Gorman, Andrew Stephen Mulato, Martin Sunkwang Rhee, Charles William Rowe, Scott P. Sellers, Dimitrios Stefanidis, Winston C. Tse, Stephen R. Yant
  • Patent number: 10537565
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: January 21, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • Publication number: 20190234945
    Abstract: Provided herein are methods, assays and devices for the detection and diagnosis of autoimmune diseases, including systemic lupus erythematosus. The methods, assays and devices provided herein analyzes binding patterns of peripheral-blood antibodies on peptide array that correlates well with current systemic lupus erythematosus clinical assessment standards.
    Type: Application
    Filed: June 20, 2017
    Publication date: August 1, 2019
    Applicant: HealthTell Inc.
    Inventors: Michael William ROWE, Theodore Michael TARASOW, Jonathan Scott MELNICK
  • Patent number: 10274294
    Abstract: A cartridge casing comprising a casing tube formed substantially of metal with a closed end and an open end. The casing tube bounds at least part of a head cap entered into the open end of the tube. The head cap is fixed relative to the tube. An end wall defines the closed end opposite the head cap end of the cartridge. The end wall comprises a weakened region.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: April 30, 2019
    Assignee: BAE Systems plc
    Inventors: James Edward Baxter, Nathan William Rowe, Joshua Matthew Stubbs
  • Publication number: 20190070162
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Application
    Filed: February 20, 2018
    Publication date: March 7, 2019
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • Patent number: 10209042
    Abstract: A cartridge casing comprises a casing tube having a first end and a head cap. The first end of the casing tube abuts and is joined with the head cap such that an orifice in the first end of the casing tube is aligned with a passage in the head cap to define a flash passage. The head cap and casing tube are held together by a deformable member.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: February 19, 2019
    Assignee: BAE SYSTEMS plc
    Inventors: James Edward Baxter, Joshua Matthew Stubbs, Nathan William Rowe
  • Publication number: 20180370950
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Application
    Filed: June 25, 2018
    Publication date: December 27, 2018
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • Patent number: 10071985
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 11, 2018
    Assignee: Gilead Sciences, Inc.
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • Publication number: 20180209769
    Abstract: A cartridge casing comprises a casing tube and a head cap. The casing tube bounds at least part of the head cap. The head cap is being fixed relative to the tube by a welding process.
    Type: Application
    Filed: September 25, 2015
    Publication date: July 26, 2018
    Applicant: BAE SYSTEMS plc
    Inventors: JAMES EDWARD BAXTER, JOSHUA MATTHEW STUBBS, NATHAN WILLIAM ROWE
  • Patent number: 9931334
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: April 3, 2018
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • Publication number: 20180058829
    Abstract: A cartridge casing comprising a casing tube formed substantially of metal with a closed end and an open end. The casing tube bounds at least part of a head cap entered into the open end of the tube. The head cap is fixed relative to the tube. An end wall defines the closed end opposite the head cap end of the cartridge. The end wall comprises a weakened region.
    Type: Application
    Filed: March 1, 2016
    Publication date: March 1, 2018
    Applicant: BAE SYSTEMS plc
    Inventors: JAMES EDWARD BAXTER, Nathan William Rowe, Joshua Matthew Stubbs
  • Publication number: 20180051005
    Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
    Type: Application
    Filed: August 17, 2017
    Publication date: February 22, 2018
    Inventors: Michael Graupe, Steven J. Henry, John O. Link, Charles William Rowe, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
  • Publication number: 20170307343
    Abstract: A cartridge casing comprises a casing tube having a first end and a head cap. The first end of the casing tube abuts and is joined with the head cap such that an orifice in the first end of the casing tube is aligned with a passage in the head cap to define a flash passage. The head cap and casing tube are held together by a deformable member.
    Type: Application
    Filed: September 25, 2015
    Publication date: October 26, 2017
    Applicant: BAE SYSTEMS plc
    Inventors: JAMES EDWARD BAXTER, JOSHUA MATTHEW STUBBS, NATHAN WILLIAM ROWE