Abstract: A system generates executable prior authorization drug request rules using a compiler. A data repository stores drug criteria. The system is configured to generate a criteria specification user interface that enables a user to specify exclusion criteria, inclusion criteria, preferred or step therapy criteria, concurrent therapy criteria, assessment criteria, quantity limits, and/or refill instructions. A prescription prior authorization rules compiler module is configured to access a criteria specification for the drug from the repository and to automatically compile the criteria specification into executable prescription prior authorization rules. A drug criteria object generation module is configured to generate a drug criteria object for the drug, including drug criteria object identification information, the executable prescription prior authorization rules, a data dictionary, and/or canonical data.