Patents by Inventor William S. Adney
William S. Adney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10036051Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.Type: GrantFiled: May 12, 2017Date of Patent: July 31, 2018Assignee: Alliance for Sustainable Energy, LLCInventors: William S. Adney, Gregg T. Beckham, Eric Jarvis, Michael E. Himmel, Stephen R. Decker, Jeffrey G. Linger, Kara Podkaminer, John O. Baker, Larry Taylor, II, Qi Xu, Arjun Singh
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Publication number: 20170247731Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.Type: ApplicationFiled: May 12, 2017Publication date: August 31, 2017Inventors: William S. ADNEY, Gregg T. BECKHAM, Eric JARVIS, Michael E. HIMMEL, Stephen R. DECKER, Jeffrey G. LINGER, Kara PODKAMINER, John O. BAKER, Larry TAYLOR, II, Qi XU, Arjun SINGH
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Patent number: 9683248Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.Type: GrantFiled: December 17, 2012Date of Patent: June 20, 2017Assignee: Alliance for Sustainable Energy, LLCInventors: William S. Adney, Gregg T. Beckham, Eric Jarvis, Michael E. Himmel, Stephen R. Decker, Jeffrey G. Linger, Kara Podkaminer, John O. Baker, Larry Taylor, II, Qi Xu, Arjun Singh
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Publication number: 20140322765Abstract: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.Type: ApplicationFiled: December 17, 2012Publication date: October 30, 2014Inventors: William S. Adney, Gregg T. Beckham, Eric Jarvis, Michael E. Himmel, Stephen R. Decker, Jeffrey G. Linger, Kara Podkaminer, John O. Baker, Larry Taylor, II, Qi Xu, Arjun Singh
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Publication number: 20140030769Abstract: Disclosed herein are combinations of free fungal enzymes and cellulosomes useful for the hydrolysis of cellulose and the conversion of biomass. Methods of degrading cellulose and biomass using the combinations are also disclosed.Type: ApplicationFiled: July 29, 2013Publication date: January 30, 2014Applicant: Alliance for Sustainable Energy, LLCInventors: Michael RESCH, John O. BAKER, Xu QI, William S. ADNEY, Steven R. DECKER, Michael E. HIMMEL, Bryon DONOHOE
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Patent number: 8637293Abstract: Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the mutations reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. Also provided herein is an isolated Cel7A polypeptide comprising increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The increased O-linked glycosylation is a result of the addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide. In some embodiments, the isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide further comprises increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide.Type: GrantFiled: May 19, 2008Date of Patent: January 28, 2014Assignee: Alliance for Sustainable Energy, LLCInventors: William S. Adney, Michael E. Himmel, Stephen R. Decker, Eric P. Knoshaug, Mark R. Nimlos, Michael F. Crowley, Tina Jeoh
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Patent number: 8283150Abstract: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A)) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native enzyme, as well as recombinantly expressed enzyme, for example, that enzyme expressed in a non-native Aspergillus host. In a specific example, the specific performance of the formulation using purified recombinant Cel7A from Penicillium funiculosum expressed in A. awamori is increased by more than 200% when compared to a formulation using purified Cel7A from Trichoderma reesei.Type: GrantFiled: October 8, 2008Date of Patent: October 9, 2012Assignee: Alliance for Sustainable Energy, LLCInventors: William S. Adney, John O. Baker, Stephen R. Decker, Yat-Chen Chou, Michael E. Himmel, Shi-You Ding
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Patent number: 7932054Abstract: The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus, and, like many cellulases, the disclosed polypeptide and/or its derivatives may be useful for the conversion of biomass into biofuels and chemicals.Type: GrantFiled: April 16, 2009Date of Patent: April 26, 2011Assignee: Alliance for Sustainable Energy, LLCInventors: William S. Adney, Todd B. Vinzant, Shih-You Ding, Michael E. Himmel
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Publication number: 20100136667Abstract: The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus, and, like many cellulases, the disclosed polypeptide and/or its derivatives may be useful for the conversion of biomass into biofuels and chemicals.Type: ApplicationFiled: April 16, 2009Publication date: June 3, 2010Applicant: ALLIANCE FOR SUSTAINABLE ENERGY, LLCInventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
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Publication number: 20090162916Abstract: Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the mutations reduce N-linked glycosylation of the isolated polypeptide relative to the wild type polypeptide. Also provided herein is an isolated Cel7A polypeptide comprising increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide. The increased O-linked glycosylation is a result of the addition of and/or substitution of one or more serine and/or threonine residues to the linker domain relative to the linker domain of the wild type polypeptide. In some embodiments, the isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide further comprises increased O-linked glycosylation of the linker domain relative to a linker domain of a wild type Cel7A polypeptide.Type: ApplicationFiled: May 19, 2008Publication date: June 25, 2009Applicant: Alliance for Sustainable Energy, LLCInventors: William S. Adney, Michael E. Himmel, Stephen R. Decker, Eric P. Knoshaug, Mark R. Nimlos, Michael F. Crowley, Tina Jeoh
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Patent number: 7538200Abstract: The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus and, like many cellulases, the disclosed polypeptide and/or its derivatives may be useful for the conversion of biomass into biofuels and chemicals.Type: GrantFiled: October 18, 2002Date of Patent: May 26, 2009Assignee: Alliance for Sustainable Energy, LLCInventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
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Publication number: 20090081762Abstract: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A)) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native enzyme, as well as recombinantly expressed enzyme, for example, that enzyme expressed in a non-native Aspergillus host. In a specific example, the specific performance of the formulation using purified recombinant Cel7A from Penicillium funiculosum expressed in A. awamori is increased by more than 200% when compared to a formulation using purified Cel7A from Trichoderma reesei.Type: ApplicationFiled: October 8, 2008Publication date: March 26, 2009Applicant: ALLIANCE FOR SUSTAINABLE ENERGY, LLCInventors: William S. Adney, John O. Baker, Stephen R. Decker, Yat-Chen Chou, Michael E. Himmel, Shi-You Ding
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Patent number: 7449550Abstract: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native enzyme, as well as recombinantly expressed enzyme, for example, that enzyme expressed in a non-native Aspergillus host. In a specific example, the specific performance of the formulation using purified recombinant Cel7A from Penicillium funiculosum expressed in A. awamori is increased by more than 200% when compared to a formulation using purified Cel7A from Trichoderma reesei.Type: GrantFiled: February 27, 2003Date of Patent: November 11, 2008Assignee: Alliance For Sustainable Energy, LLCInventors: William S. Adney, John O. Baker, Stephen R. Decker, Yat-Chen Chou, Michael E. Himmel, Shi-You Ding
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Patent number: 7393673Abstract: The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as Gux1. Gux1 has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified Gux1. Methods of making and using Gux1 polypeptides, including fusions, variants, and derivatives, are also disclosed.Type: GrantFiled: July 28, 2001Date of Patent: July 1, 2008Assignee: Midwest Research InstituteInventors: William S. Adney, Shi-You Ding, Todd B. Vinzant, Michael E. Himmel, Stephen R. Decker, Suzanne Lantz McCarter
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Patent number: 7375197Abstract: The disclosure provides a method for preparing an active exoglucanase in a heterologous host of eukaryotic origin. The method includes mutagenesis to reduce glycosylation of the exoglucanase when expressed in a heterologous host. It is further disclosed a method to produce variant cellobiohydrolase that is stable at high temperature through mutagenesis.Type: GrantFiled: January 14, 2002Date of Patent: May 20, 2008Assignee: MidWest Research InstituteInventors: William S. Adney, Stephen R. Decker, Suzanne Mc Carter, John O. Baker, Raphael Nieves, Michael E. Himmel, Todd B. Vinzant
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Patent number: 7364890Abstract: The invention provides a thermal tolerant (thermostable) cellulase, AviIII, that is a member of the glycoside hydrolase (GH) family. AviIII was isolated and characterized from Acidothermus cellulolyticus and, like many cellulases, the disclosed polypeptide and/or its derivatives may be useful for the conversion of biomass into biofuels and chemicals.Type: GrantFiled: July 28, 2001Date of Patent: April 29, 2008Assignee: Midwest Research InstituteInventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
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Patent number: 7112429Abstract: The invention provides a thermal tolerant mannanase that is a member of the glycoside hydrolase family. The invention further discloses this mannanase as ManA. ManA has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified ManA. Methods of making ManA polypeptides, including fusions, variants, and derivatives, are also disclosed. Methods of using mannanase A, including for the processing of food and for use in food stuffs as bulking agents and the like, are also disclosed.Type: GrantFiled: July 28, 2001Date of Patent: September 26, 2006Assignee: Midwest Research InstituteInventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
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Patent number: 7059993Abstract: The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as GuxA. GuxA has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified GuxA. Methods of making and using GuxA polypeptides, including fusions, variants, and derivatives, are also disclosed.Type: GrantFiled: July 28, 2001Date of Patent: June 13, 2006Assignee: Midwest Research InstituteInventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel, Stephen R. Decker
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Publication number: 20040038334Abstract: The invention provides a thermal tolerant (thermostable) cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as AviIII. AviIII has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified AviIII. Methods of making and using AviIII polypeptides, including fusions, variants, and derivatives, are also disclosed.Type: ApplicationFiled: July 28, 2001Publication date: February 26, 2004Inventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
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Publication number: 20030170861Abstract: A nucleic acid molecule having a nucleic acid sequence that encodes a linker region of exoglucanase, said nucleic acid sequence comprising the nucleic sequence 5′-GGCGGAAACCCGCCTGGCACCACC-3′.Type: ApplicationFiled: January 14, 2002Publication date: September 11, 2003Inventors: William S. Adney, Stephen R. Decker, Suzanne McCarter, John O. Baker, Rafael Nieves, Michael E. Himmel, Todd B. Vinzant