Abstract: A method and system for use in the course of extracorporeal blood flow, e.g., cardiopulmonary bypass, dialysis, and angioplasty procedures, in order to reduce or minimize inflammation, excessive bleeding, and other undesirable side effects. The system can include one or more automated blood parameter sensor modules and one or more blood parameter regulating modules. The system is particularly well suited to monitor and/or regulate blood parameters that include blood analytes (e.g., biomolecules, drugs or metabolites) as well as blood functions (e.g., clotting time, fibrinolytic activity, immune response). The system is particularly well suited for use in the management of clotting (e.g., heparing/protamine) and bleeding (e.g., aprotinin).

Abstract: A method and system for use in the course of extracorporeal blood flow, e.g., cardiopulmonary bypass, dialysis, and angioplasty procedures, in order to reduce or minimize inflammation, excessive bleeding, and other undesirable side effects. The system can include one or more automated blood parameter sensor modules and one or more blood parameter regulating modules. The system is particularly well suited to monitor and/or regulate blood parameters that include blood analytes (e.g., biomolecules, drugs or metabolites) as well as blood functions (e.g., clotting time, fibrinolytic activity, immune response). The system is particularly well suited for use in the management of clotting (e.g., heparing/protamine) and bleeding (e.g., aprotinin).

Abstract: A method and system for use in the course of extracorporeal blood flow, e.g., cardiopulmonary bypass, dialysis, and angioplasty procedures, in order to reduce or minimize inflammation, excessive bleeding, and other undesirable side effects. The system can include one or more automated blood parameter sensor modules and one or more blood parameter regulating modules. The system is particularly well suited to monitor and/or regulate blood parameters that include blood analytes (e.g., biomolecules, drugs or metabolites) as well as blood functions (e.g., clotting time, fibrinolytic activity, immune response). The system is particularly well suited for use in the management of clotting (e.g., heparing/protamine) and bleeding (e.g., aprotinin).

Abstract: The present invention relates to an apparatus for monitoring blood parameters during cardio-pulmonary bypass surgery or during other procedures which utilize an extracorporeal circuit. The apparatus is typically used to monitor the percentage of hemoglobin bound with oxygen (oxygen saturation), the total amount of hemoglobin in the blood, and the percent of blood which is comprised of red blood cells (hematocrit), although the apparatus can be adapted to measure other blood parameters. The apparatus (or monitor) provides real-time results to show immediate changes (trending) in the monitored parameters.

Abstract: An arterial line blood filter for use in extracorporeal blood circuits during heart bypass surgery. The blood filter includes a housing having a cap portion, a base portion and a generally cylindrical wall portion. A filter element is disposed within the housing and divides the housing into an inlet chamber in flow communication with a blood inlet and an outlet chamber in flow communication with a blood outlet. The filter element may include a plurality of concentric annular pleats, the length of which may be substantially equal to the length of the wall portion, the pleats being supported by a support element. In another embodiment the inner surface of the cap defines an inwardly spiral blood flow path which slopes upward and provides an effective means of distributing blood over the filter element.

Abstract: A mass transfer device including a hollow fiber bundle wound on a core for radially outward flow of a first fluid. The core has an axis extending from one end to the other. The hollow fiber bundle has packing fractions which increase radially outward of the core's axis for a major portion of the bundle. Methods for making such mass transfer device.

Abstract: A mass transfer device including a hollow fiber bundle wound on a core for radially outward flow of a first fluid. The core has an axis extending from one end to the other. The hollow fiber bundle has packing fractions which increase radially outward of the core's axis for a major portion of the bundle. Methods for making such mass transfer device.

Abstract: A radial flow hollow fiber blood oxygenator is provided. The oxygenator includes a hollow fiber bundle within an oxygenator chamber defined by a hollow core around which the hollow fibers are wound and an outer housing. A gas entry port is coupled to the interior of the fibers adjacent one end of the bundle and a gas outlet is coupled to the interior of the fibers at the opposite end of the bundle. A blood inlet to the core is provided adjacent one end of the bundle, and a blood outlet from the chamber is provided adjacent the same end of the bundle. The direction of blood flow through the chamber is generally radial and the oxygenator includes an inlet manifold and an outlet manifold.

Abstract: A dialyser has a membrane assembly (14) comprising two U-shaped conduits partially defined, and separated, by a transfer membrane wall. The walls of the conduits are provided with furrowing at an inclination to the direction of flow through the conduit. Blood is pumped through one conduit by a roller pump (16) in series with a reciprocatory pump (18) and dialysate is pumped in counter current through the other conduit by a roller pump (23) in series with a reciprocatory pump (25). The reciprocatory pumps (18,25) are operated in phase so that the resulting pulsatile component in the two conduits is in phase. This pulsatile flow, in conjunction with the furrows, produces vortexes in, and good mixing of, the blood and dialysate in their respective conduits and hence enhanced contact of each of these liquids with the transfer membrane wall.

Abstract: A dialyser has a membrane assembly (12) comprising two superposed conduits partially defined, and separated, by a transfer membrane wall. The walls of the conduit are provided with furrowing (38 or 39) extending with a component along the conduits. Blood is pumped through one conduit by a roller pump (21) and dialysate is pumped in counter current through the other conduit by a roller pump (24). The conduits communicate with separate chambers in flexible bladders (16) along each side edge of the conduits and the bladders are alternately compressed by rollers (27) to provide a superimposed reciprocatory flow component on the blood and dialysate in a direction transverse to the length of the conduits. This reciprocatory flow component, in conjunction with the furrows, produces vortexes in, and good mixing of, the blood and dialysate in their respective conduits and hence enhanced contact of each of these liquids with the transfer membrane wall.

Abstract: A mass transfer device including a hollow fiber bundle wound on a core for radially outward flow of a first fluid. The core has an axis extending from one end to the other. The hollow fiber bundle has packing fractions which increase radially outward of the core's axis for a major portion of the bundle. Methods for making such mass transfer device.