Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: A therapy utilizing inhaled anesthetic agents (such as desflurane, sevoflurane, isoflurane, or xenon) for the sedation of patients outside of the immediate perioperative space such as in the medical intensive care unit (MICU) and the surgical intensive care unit (SICU). The therapy includes controlled delivery of volatile anesthetic agents to patients undergoing ventilatory support on an ICU ventilator over extended periods of time. A system which provides for the delivery of anesthetic agents includes an anesthetic agent vaporizer element, an anesthetic agent reflector, and a plug-in cassette which contains both a cartridge housing liquid phase volatile anesthetic agent and an anesthetic vapor scrubbing medium.

Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.

Abstract: A therapy utilizing inhaled anesthetic agents (such as desflurane, sevoflurane, isoflurane, or xenon) for the sedation of patients outside of the immediate perioperative space such as in the medical intensive care unit (MICU) and the surgical intensive care unit (SICU). The therapy includes controlled delivery of volatile anesthetic agents to patients undergoing ventilatory support on an ICU ventilator over extended periods of time. A system which provides for the delivery of anesthetic agents includes an anesthetic agent vaporizer element, an anesthetic agent reflector, and a plug-in cassette which contains both a cartridge housing liquid phase volatile anesthetic agent and an anesthetic vapor scrubbing medium.

Abstract: The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.

Abstract: A container (10) having a plurality of panels (12–18) joined together to form a sleeve (64). The panels (12–18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12–18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.

Abstract: A container (10) having a plurality of panels (12–18) joined together to form a sleeve (64). The panels (12–18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12–18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.

Abstract: The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.

Abstract: The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend and (B) the second layer is disposed coaxially within the first layer; and the membrane tube (II) is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.

Abstract: The present invention provides a system and method for delivering fluid. In one embodiment, the system and method include a container to hold the fluid, and a closed-end tube having a first end in communication with the container and a closed second end. The closed second end is contoured in a pattern to form a zone of weakness. The zone of weakness facilitates reduced force necessary for an access spike to puncture the closed second end.

Abstract: The present invention provides a system and method for delivering fluid. In one embodiment, the system and method include a container to hold the fluid, and a closed-end tube having a first end in communication with the container and a closed second end. The closed second end is contoured in a pattern to form a zone of weakness. The zone of weakness facilitates reduced force necessary for an access spike to puncture the closed second end.

Abstract: The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.

Abstract: A container (10) having a plurality of panels (12-18) joined together to form a sleeve (64). The panels (12-18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12-18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.

Abstract: A container (10) having a plurality of panels (12-18) joined together to form a sleeve (64). The panels (12-18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12-18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.

Abstract: A container (10) having a plurality of panels (12-18) joined together to form a sleeve (64). The panels (12-18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20, 22) connected to the panels (12-18) at the one end of the sleeve (64). The end panel (20, 22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.

Abstract: A container (10) having a plurality of panels (12-18) joined together to form a sleeve (64). The panels (12-18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12-18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.