Patents by Inventor William S. Stavropoulos

William S. Stavropoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of triglycerides and glycerol
    Patent number: 4142938
    Abstract: Triglycerides in biological fluids containing interfering substances, such as phospholipids, are determined by hydrolyzing the triglycerides to glycerol in a short time span at moderate temperatures with a solution of alkali metal hydroxide in methanol, and treating the resultant hydrolysis mixture with a water soluble magnesium salt to precipitate the interfering substances. Glycerol is then colorimetrically determined in the resultant supernatant solution by incubating with a single reagent-substrate composition to develop a measurable color.
    Type: Grant
    Filed: October 8, 1976
    Date of Patent: March 6, 1979
    Assignee: The Dow Chemical Company
    Inventors: William S. Stavropoulos, Robert D. Crouch
  • Decarboxylation of endogenous serum glutamate in transaminase assays
    Patent number: 4086142
    Abstract: A spectrophotometric method for carrying out transaminase determinations of biological fluids wherein endogenous glutamate in a biological fluid is decarboxylated prior to transaminase determinations with bacterial glutamic acid decarboxylase.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: April 25, 1978
    Assignee: The Dow Chemical Company
    Inventors: Charles Y. Huang, William S. Stavropoulos
  • Determination of glutamate and glutamic transaminases
    Patent number: 4024021
    Abstract: Glutamate and glutamic transaminases are determined by mixing a substrate-reagent composition that is essentially free of ammonia or ammonium ions with a specimen to be analyzed, incubating the resulting mixture for less than about 15 minutes, terminating incubation and measuring a color produced.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: May 17, 1977
    Assignee: The Dow Chemical Company
    Inventors: William S. Stavropoulos, Kenneth J. Acuff
  • Determination of creatine phosphokinase in body fluids
    Patent number: 4012286
    Abstract: An improved method and compositions useful for determining the creatine phosphokinase activity of body fluids suitable for use on clinical colorimeters which involves pre-activation of the creatine phosphokinase with a novel pre-activation composition and comparison to a chemical standard.
    Type: Grant
    Filed: April 9, 1976
    Date of Patent: March 15, 1977
    Assignee: The Dow Chemical Company
    Inventors: James Allen Sanderson, William S. Stavropoulos
  • Method for determination of triglycerides and glycerol
    Patent number: 4001089
    Abstract: A novel reagent and method for colorimetrically determining the concentration of triglycerides in biological fluids, and for rapid determination of glycerol are described. Triglycerides are hydrolyzed in methanolic base to glycerol, and glycerol content is determined colorimetrically.
    Type: Grant
    Filed: March 20, 1974
    Date of Patent: January 4, 1977
    Assignee: The Dow Chemical Company
    Inventors: William S. Stavropoulos, Robert D. Crouch
  • Determination of calcium
    Patent number: 3938954
    Abstract: An improved reagent system for determining calcium by the orthocresolphthalein complexone color reaction. The reagent utilizes an alkaline buffer containing an aminoloweralkanol providing a pH of about 10.2 - 10.5. A method for using the reagent is also described. The composition is stable for extended periods.
    Type: Grant
    Filed: January 20, 1975
    Date of Patent: February 17, 1976
    Assignee: The Dow Chemical Company
    Inventors: William S. Stavropoulos, Bernard J. Thiegs, Robert F. Mack