Abstract: A snap ring retainer system includes a first member having an annular groove therein. A second member is engaged with the first member. A snap ring is received in the annular groove and includes a first side engaging the second member and securing the second member to the first member. A snap ring retainer includes a first portion engaged with the first member and a second portion extending radially from the first portion and engaged with the snap ring on an opposite side from the second member.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: An athletic training device is provided for determining the forward rotation of the hand in relation to the wrist of an athlete. The device comprises a pair of bands, a first band disposed about the wrist and a second band disposed about the knuckles of a hand of an athlete. A strap is connected between the two bands. The length of the strap is greater than the distance between the two bands when the hand is not rotated forwardly. When the wrist is rotated forwardly, the strap is placed under tension and pulled toward the hand of the athlete. This movement of the strap triggers a sensing mechanism, which in turn closes a circuit and triggers a signalling mechanism. Thus, an athlete can determine when complete forward rotation of his or her wrist has occurred. In a preferred embodiment, the signalling mechanism includes an audible sound generating device.

Abstract: A novel masonry tool kit that enables masons to plumb their work quickly and easily which saves time and money. The invention consists of two vertical members or story poles which operate in two systems. One system is used for outside corners and the other for inside corners. The vertical members or story poles have markings to save time so brick courses will be pre-gauged which prevents uneven courses on the wall. The lower L shaped members give stability so that the masonry line can be pulled tight and true with no movement. The masonry guide provides a simplified method of insuring accuracy with quality craftsmanship in masonry work. This masonry tool kit eliminates the need to shim or build a lead at the top of the foundation inside or outside corners as the lower L shaped members secure the vertical member or story pole in the correct position.

Abstract: A cooking apparatus has two plates which apply heat and pressure to cook an initial food material, wherein one plate is movable toward the other plate manually to close a cooking space, then is moved by a drive to apply a pressure to the food material, and is urged to an open position by a spring.

Abstract: An apparatus for cooking food has two plates which can be heated and of which one plates is movable relative to the other to apply heat and pressure to an initial food material for cooking the same, wherein a drive for moving the one plate is formed as a magnetic drive located laterally outside the contours of the plates.

Abstract: An apparatus for cooking food includes two plates, a heating device for heating the plates, a drive for driving one of the plates relative to the other so as to apply heat and pressure to an initial food material, and the drive is formed so that the one plate moves in a stepped manner. One of the plates can be movable or even removable in a different direction to provide for easy handling. A protective element can be placed between the plates and the initial food material during cooking, and withdrawn thereafter.

Abstract: An apparatus for cooking food includes two solid plates which subject an initial food material to high heat and pressure, and the pressure is adjusted in dependence upon the nature of the initial food material by an adjusting device.