Abstract: Antibodies and antigen-binding fragments thereof that bind type II transmembrane serine protease 6 (TMPRSS6) on the surface of a cell and increase hepcidin expression, and methods for treating disorders of iron metabolism and myeloproliferative disorders using anti-TMPRSS6 antibodies and fragments, are provided.

Abstract: The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use. In accordance with the compositions and methods described herein, mobilized hematopoietic stem and progenitor cells can be withdrawn from a donor and administered to a patient for the treatment of various stem cell disorders, including hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.

Abstract: An aircraft propulsion system comprises a power plant driving a number of outboard propulsion units to propel a fixed wing aircraft.

Abstract: Amplifier comprising an input signal node for conveying an input signal having an input signal value and an output signal node for conveying an output signal having an output signal value. Amplifier circuitry is coupled to the input signal node and provided with a plurality of intermediate output signal nodes, each for conveying an intermediate output signal having an intermediate output signal value. The intermediate output signal value in each intermediate output signal node relates to the input signal value in accordance with predetermined signal gains. A signal selector selects one of the intermediate output signals and feeds the selected one to the output signal node. The amplifier may be comprised in an analogue to digital converter. The amplifier may be incorporated in a down hole tool. The method of amplification may be used in a method of producing a mineral hydrocarbon fluid.

Abstract: Savage Wonder Reel, connected to any 2? square trailer receiver hitch and wound with rope, can be used to pull wire through conduit from any angle and from any brake drag setting. This reel can also be used to spool-off small wire, such as TV and telephone cable.

Abstract: A nacelle for housing a gas turbine engine is disclosed. The nacelle comprises an inlet lip defining a leading edge of the nacelle and a conduit located within the inlet lip, the conduit having a fluid circulating therein. The fluid provides a heat source. An energy attenuating member is located within the inlet lip between the leading edge and the conduit. The energy attenuating member provides protection to the conduit from foreign object damage and is thermally conductive such that heat transfer communication between the conduit and the leading edge is provided.

Abstract: An aircraft propulsion system comprises a power plant driving a number of outboard propulsion units to propel a fixed wing aircraft.

Abstract: A folding chair includes a seat defining a top sitting area adapted for supporting a user in a sitting position. A back extends outwardly from the seat in an open chair position, and defines a back support area for engaging a back of the user. A hinge pivotably connects the seat and the back whereby at least one of the seat and back is moveable from the open chair position to a closed chair position. In the closed chair position, the back support and sitting areas reside in overlying relation within a common perimeter. The common perimeter is secured against entry of outside elements such that the back support and sitting areas remain clean when the chair is returned to the open chair position.