Patent number: RE35904
Abstract: The present invention is directed to compounds capable of binding to the es nucleoside transporter of animal cells having the general formula: ##STR1## wherein n is 1-12; E is H, halogen, NH.sub.2, OH, OCH.sub.3, O(CH.sub.2).sub.n CH.sub.3 (where n is 1 to 12), SH, SR (where R is CH.sub.3 or (CH.sub.2).sub.n CH.sub.3 and n is 1 to 12); A is HN, S, O, Se; X is N or C; Y is N or C; Z is N or C; R.sub.1 is H or acyl; R.sub.2 is C1 to C20 substituted or unsubstituted alkyl or heteroalkyl; substituted or unsubstituted aliphatic carbocycle or heterocycle; substituted or unsubstituted arene or heteroarene, aryl or substituted aryl; heteroaryl or substituted heteroaryl; R.sub.3 is H, halogen, NO.sub.2, N.sub.3, SH, SR (where R is CH.sub.3 or (CH.sub.2).sub.n CH.sub.3 and n is 1 to 12) .Iadd.when Y is C and R.sub.3 is absent when Y is N.Iaddend.; R.sub.4 is H, OH .?.is.!. .Iadd.or .Iaddend.halogen; R.sub.5 is H, OH, halogen, N.sub.3, acetal, hemiacetal.Iadd.; .Iaddend.and R.sub.6 is H, .?.--C.dbd.O--HN.sub.2 .!. .
Type:
Grant
Filed:
August 17, 1995
Date of Patent:
September 22, 1998
Assignee:
Governors of the University of Alberta
Inventors:
Alan R. P. Paterson, Carol E. Cass, Wendy P. Gati, John K. Buolamwini, Gary P. Jamieson, David P. McAdam, William A. Sawyer, James S. Wiley, James D. Craik, Morris J. Robins