Abstract: A kayak anchor support system includes a first support arm having a first end opposite a second end, wherein the first support arm is removably securable to a kayak via at least one mounting bracket. A proximal end of a second support arm is affixed to the first support arm adjacent to the first end. The second support arm extends orthogonally from the first support arm such that a distal end of the second support arm is maintained in an elevated position above the kayak. A pulley is affixed to the distal end of the second support arm. An anchor cable is engaged with each of the pulley and a reel, wherein the reel is disposed opposite the pulley. An anchor is affixed to a terminal end of the anchor cable, whereupon actuation of the reel, the anchor is selectively movable between a raised position and a lowered positioned.

Abstract: An emergency trailer wheel assembly for temporarily replacing a trailer wheel includes a frame member with a mounting bracket attached on a first end of the frame member and configured for attaching to a leaf spring of a trailer and a wheel rotatably attached to a second end of the frame member.

Abstract: A kayak anchor support system includes a first support arm having a first end opposite a second end, wherein the first support arm is removably securable to a kayak via at least one mounting bracket. A proximal end of a second support arm is affixed to the first support arm adjacent to the first end. The second support arm extends orthogonally from the first support arm such that a distal end of the second support arm is maintained in an elevated position above the kayak. A pulley is affixed to the distal end of the second support arm. An anchor cable is engaged with each of the pulley and a reel, wherein the reel is disposed opposite the pulley. An anchor is affixed to a terminal end of the anchor cable, whereupon actuation of the reel, the anchor is selectively movable between a raised position and a lowered positioned.

Abstract: An emergency trailer wheel assembly for temporarily replacing a trailer wheel includes a frame member with a mounting bracket attached on a first end of the frame member and configured for attaching to a leaf spring of a trailer and a wheel rotatably attached to a second end of the frame member.

Abstract: A mobility aid in the form of a cuff crutch can be used in various configurations. The cuff crutch includes an arm cuff positioned at a distal end of a tube that is adjustably positioned into a main tube of the crutch. The main tube may be bent at an angle in a position below a mid-point thereof, that is, the bend is closer to the foot end of the main tube as opposed to the cuff end thereof. A foot tube may be adjustably positioned into the foot end of the main tube and a foot may be disposed on a distal end of the foot tube. By providing the various adjustments, the cuff crutch may be used as a cuff cane, a cuff crutch or a walking stick, as discussed herein. The cuff, grip, and foot may include designs that offer various improvements over conventional mobility aids.

Abstract: A mobility aid, in the form of a walking stick, can be used in various configurations. The walking stick can have a grip on an upper end thereof, a foot on a lower end thereof, a wrist strap near the grip, and a height adjustment feature to permit height adjustment of the walking stick. The height adjustment feature can take forms, such as a twist-lock, a pin and hole adjustment, telescoping members, and the like. The foot may include a water treading design to help prevent slippage of the foot on a wet surface.

Abstract: A kayak anchor support system includes a first support arm having a first end opposite a second end, wherein the first support arm is removably securable to a kayak via at least one mounting bracket. A proximal end of a second support arm is affixed to the first support arm adjacent to the first end. The second support arm extends orthogonally from the first support arm such that a distal end of the second support arm is maintained in an elevated position above the kayak. A pulley is affixed to the distal end of the second support arm. An anchor cable is engaged with each of the pulley and a reel, wherein the reel is disposed opposite the pulley. An anchor is affixed to a terminal end of the anchor cable, whereupon actuation of the reel, the anchor is selectively movable between a raised position and a lowered positioned.

Abstract: At least one emitter formed of an electron emissive material is positioned on a cathode assembly and is readily and reliably connected to at least one mounting member of the cathode assembly. The connections between the at least one emitter and an emitter support structure are formed directly between the at least one emitter and the emitter support structure by utilizing the at one mounting member on the emitter support structure that are positioned adjacent the at least one emitter and heated to secure the at least one emitter to the emitter support structure by welding the at least one mounting member to the at least one emitter and emitter support structure.

Abstract: Various safety systems for power tools, and in particular table saws include detection systems for detecting a dangerous condition relative to a blade of the power tool, reaction systems for taking mitigation action in response to detection of a dangerous condition. The safety system may detect, prevent, and/or mitigate a dangerous condition associated with the power tool.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: At least one emitter formed of an electron emissive material is positioned on a cathode assembly and is readily and reliably connected to at least one mounting member of the cathode assembly. The connections between the at least one emitter and an emitter support structure are formed directly between the at least one emitter and the emitter support structure by utilizing the at one mounting member on the emitter support structure that are positioned adjacent the at least one emitter and heated to secure the at least one emitter to the emitter support structure by welding the at least one mounting member to the at least one emitter and emitter support structure.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include an axilla support that has a shape with a peak that fits in the center of the user's axilla area, an increased width for the pad area in the peaked region, a feature that curves upward and toward the user's back to prevent forward slippage of the axilla support, and a feature that includes upward curves or widened areas to prevent rearward slippage of the axilla support. The crutches can include a grip that has a wider rear portion when viewed from the top, a downward slope from rear to front, a front area that narrows and twists towards the outside from horizontal, an offset from the centerline of the crutches to the outside and a rear that is rotated outward from the support centerline when viewed from the top.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include one or more linkage devices that provide a mechanism to link the crutches together and provide restrictions on the range of motion, improving confidence and safety of the crutch devices. A first linkage device can be designed to attach to an upper portion of the crutch frame or at the axilla support to be placed along a user's back. A second linkage device can be designed to wrap about a waist area of a user and attach to a central portion of the crutch frame or at the grip region. The first and second linkages may be used singularly or in combination.

Abstract: Mobility aid devices, such as crutches, provide improved ergonomics, comfort and support for the user. The crutches can include a frame configuration where a main frame member includes a lower adjustment pole extending therefrom and a secondary pole is attached to a lower end of the main pole and extends upward therefrom. An axilla support may be supported by the main pole and the secondary pole. Typically, the axilla support may be supported by upper adjustment poles that adjustably telescope from the tops of the main pole and the secondary pole. The frame configuration, or a conventional frame, may be used in a crutch that can be convertible between a crutch, such as a cuff crutch, and a cane.

Abstract: Selection of HIV vaccine antigens by use of intrapatient sequence variation to identify mutations in the HIV envelope glycoprotein that affect the binding of broadly neutralizing antibodies and polypeptides identified by these methods.

Abstract: The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: LA represents an optionally substituted methylene or ethylene group; LB represents —N(H)—C(?O)— or —C(?O)—N(H)—; R1 represents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or —N(R7)(Ci-C6-alkyl) group; R2 represents an optionally substituted 5- or 6-membered heteroaryl group; R3 represents an optionally substituted phenyl group.

Abstract: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.

Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyperproliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.