Patents by Inventor William Scott Crawford
William Scott Crawford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946840Abstract: An assembly including a cassette having a support layer. At least a portion of the support layer is embedded in a recipient block formed from an agarose gel for securing the recipient block to the cassette. The recipient block has a surface spaced from the support layer and is provided with at least one bore extending from the surface into the recipient block that is adapted to receive a biological sample material. A method for forming an assembly is provided.Type: GrantFiled: March 30, 2022Date of Patent: April 2, 2024Assignee: Array Science, LLCInventors: Regan Spencer Fulton, William Scott Crawford, Trinh Kiet Hoac
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Publication number: 20230270922Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location.Type: ApplicationFiled: May 8, 2023Publication date: August 31, 2023Inventors: William Scott Crawford, Robert Matthew Ohline
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Patent number: 11679184Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on dimensions and a distensibility of a non-occluded portion of the patient line. If the change in pressure, the incremental volume, properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, a location of the occlusion can be inferred. An occlusion type can be inferred based on the location of the occlusion.Type: GrantFiled: July 7, 2021Date of Patent: June 20, 2023Assignee: Fresenius Medical Care Holdings, Inc.Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20220268661Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: ApplicationFiled: February 9, 2022Publication date: August 25, 2022Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford
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Publication number: 20220221381Abstract: An assembly including a cassette having a support layer. At least a portion of the support layer is embedded in a recipient block formed from an agarose gel for securing the recipient block to the cassette. The recipient block has a surface spaced from the support layer and is provided with at least one bore extending from the surface into the recipient block that is adapted to receive a biological sample material. A method for forming an assembly is provided.Type: ApplicationFiled: March 30, 2022Publication date: July 14, 2022Applicant: Array Science, LLCInventors: Regan Spencer Fulton, William Scott Crawford, Trinh Kiet Hoac
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Patent number: 11300486Abstract: A method for making a microarray block with a recipient block having at least one bore therein. A mold having a cylindrical bore with a cross-sectional shape approximating the cross-sectional shape of the at least one bore of the recipient block can be provided. The first end of the mold can have an opening that communicates with a cylindrical bore of the mold. A biological sample and a liquid carrier medium can be introduced through the opening and solidified in the mold to form a core. The core can be removed from the mold and at least a portion of the core can be inserted into the at least one bore of the recipient block. Related methods and assemblies are provided.Type: GrantFiled: November 24, 2017Date of Patent: April 12, 2022Assignee: Array Science, LLCInventors: Regan Spencer Fulton, William Scott Crawford, Trinh Kiet Hoac
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Patent number: 11262270Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: GrantFiled: January 17, 2020Date of Patent: March 1, 2022Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford
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Publication number: 20210330871Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location.Type: ApplicationFiled: July 7, 2021Publication date: October 28, 2021Inventors: William Scott Crawford, Robert Matthew Ohline
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Patent number: 11071809Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on dimensions and a distensibility of a non-occluded portion of the patient line. If the change in pressure, the incremental volume, properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, a location of the occlusion can be inferred. An occlusion type can be inferred based on the inferred location.Type: GrantFiled: June 30, 2016Date of Patent: July 27, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: William Scott Crawford, Robert Matthew Ohline
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Patent number: 11027054Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).Type: GrantFiled: November 27, 2018Date of Patent: June 8, 2021Assignee: Fresenius Medical Care Holdings, Inc.Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20200191682Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: ApplicationFiled: January 17, 2020Publication date: June 18, 2020Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford
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Patent number: 10539481Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: GrantFiled: January 5, 2017Date of Patent: January 21, 2020Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford
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Publication number: 20190388603Abstract: Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.Type: ApplicationFiled: September 4, 2019Publication date: December 26, 2019Inventors: William Scott Crawford, Robert Matthew Ohline
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Patent number: 10441702Abstract: Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.Type: GrantFiled: October 4, 2016Date of Patent: October 15, 2019Assignee: Fresenius Medical Care Holdings, Inc.Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20190275228Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).Type: ApplicationFiled: November 27, 2018Publication date: September 12, 2019Inventors: William Scott Crawford, Robert Matthew Ohline
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Patent number: 10172993Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).Type: GrantFiled: April 14, 2016Date of Patent: January 8, 2019Assignee: Fresenius Medical Care Holdings, Inc.Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20180093031Abstract: Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.Type: ApplicationFiled: October 4, 2016Publication date: April 5, 2018Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20180001009Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line made of a distensible material that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. When an incremental volume of additional solution is provided to the patient line while the occlusion is present, a change in pressure results. The change in pressure depends on the dimensions and the distensibility of the non-occluded portion of the patient line. If the change in pressure, the incremental volume, the properties related to the distensibility of the patient line, and some of the dimensions of the patient line are known, the location of the occlusion can be inferred. The occlusion type can be inferred based on the determined location.Type: ApplicationFiled: June 30, 2016Publication date: January 4, 2018Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20170296731Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).Type: ApplicationFiled: April 14, 2016Publication date: October 19, 2017Inventors: William Scott Crawford, Robert Matthew Ohline
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Publication number: 20170115178Abstract: A method is provided for detecting leaks in a disposable medical fluid cassette that includes a base and a flexible membrane attached to the base in such a way that the base and the flexible membrane cooperate to at least partially form a fluid passageway. The method includes applying a first force to the flexible membrane, measuring a first physical property of a system that includes the medical fluid cassette a medical fluid pumping machine, removing the first force from the flexible membrane, applying a second force to the flexible membrane, measuring a second physical property of the system, and determining whether the medical fluid cassette leaks based on a comparison of the first physical property and the second physical property.Type: ApplicationFiled: January 5, 2017Publication date: April 27, 2017Inventors: Kulwinder S. Plahey, Jie Zhu, Tri Ly, Robert Matthew Ohline, William Scott Crawford