Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: Described and featured herein are antagonistic biparatopic antibodies that specifically bind and inhibit an FGF receptor (e.g., FGFR2) and methods of using such antibodies for the treatment of cancers, including Cholangiocarcinoma (CCAs).

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: Provided herein, in some embodiments, are methods for detecting a level of asparaginase (ASNS) in a sample obtained from a subject having or at risk for stomach cancer or liver cancer, and methods of treating the subject.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: Rapamycin derivatives for use in the treatment of neurocutaneous disorders.

Abstract: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

Abstract: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

Abstract: Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing probes for genes involved in prostate cancer development are described.

Abstract: Methods identifying prostate cancer, methods for prognosing and diagnosing prostate cancer, methods for identifying a compound that modulates prostate cancer development, methods for determining the efficacy of a prostate cancer therapy, and oligonucleotide microarrays containing probes for genes involved in prostate cancer development are described.

Abstract: A method and apparatus for processing meat is provided. According to the method, a meat product is positioned within an interior volume of a decompression chamber. A pressure differential is created across a gas output in communication with the interior volume of the decompression chamber. The decompression chamber is then rapidly decompressed by transferring gas from the interior volume of the decompression chamber through the gas output. The pressure differential and the rate of the rapid decompression are selected to be suitable for processing the meat product positioned within the interior volume of the decompression chamber. Typically, the pressure differential and the rate of rapid decompression are selected to be suitable for tenderizing the meat product, killing microorganisms in the meat product, or both.

Abstract: A clinician's assistant system including examination and treatment modules to guide a clinician in examining and treating a patient. The system is configured to communicate with databases storing patient data and treatment data. The modules display information to and solicit information from a clinician via a display device, e.g. using menus and graphical user interfaces, to ensure that the patient is properly evaluated and treated. Optionally, the system is capable of recommending a treatment, e.g. as a function of patient information known to the system. The system can help create documents by presenting the clinician with selectable phrases, and/or by incorporating data into predefined document templates. The system provides multi-patient research, voice recognition, and billing capabilities. The system may be implemented, at least in part, in a pen-based portable computer so that patient medical record and/or treatment data is available, and examination data is recorded, at the point of care.

Abstract: A shock wave generator is provided incorporating a compressed gas reservoir, a high speed valve assembly, and a shock tube. The high speed valve assembly is arranged to open and close selectively a gas passage extending from the compressed gas reservoir to the shock tube. The high speed valve assembly comprises a valve sleeve, a valve seat, and a valve sleeve driving assembly. The valve sleeve is arranged to extend across the gas passage between a first side of the gas passage and a second side of the gas passage. The valve seat is arranged on the second side of the gas passage and is positioned to receive the valve sleeve upon extension of the valve sleeve across the gas passage. The valve sleeve driving assembly is arranged to cause extension and retraction of the valve sleeve across the gas passage. The valve sleeve defines a circular cross section and an epicentral valve sleeve axis and includes a valve sleeve flange arranged on a leading edge thereof.

Abstract: A method and apparatus for processing meat is provided. According to the method, a meat product is positioned within an interior volume of a decompression chamber. A pressure differential is created across a gas output in communication with the interior volume of the decompression chamber. The decompression chamber is then rapidly decompressed by transferring gas from the interior volume of the decompression chamber through the gas output. The pressure differential and the rate of the rapid decompression are selected to be suitable for processing the meat product positioned within the interior volume of the decompression chamber. Typically, the pressure differential and the rate of rapid decompression are selected to be suitable for tenderizing the meat product, killing microorganisms in the meat product, or both.

Abstract: The RF tag system of the present invention minimizes the effect of the RF tag on the overall radar cross section (RCS) of the object with which it is associated, tailors the signal reflected from the tag to match the actual RCS of the object with which it is associated, utilizes an RF tag design that reduces degenerative RF coupling at the tag, and is designed to exploit the operational features of conventional pulse Doppler radars. In accordance with one embodiment of the present invention, a radio frequency tag system is provided including an interrogator and a tag. The tag is secured to an object. The interrogator is configured to generate a transmitted electromagnetic interrogation signal at a predetermined interrogation frequency. The tag comprises an antenna array including a plurality of receiver antennas and a plurality of transmitter antennas.

Abstract: We have discovered a nuclear protein in normal human cells, "retinoblastoma-associated protein 1" ("RBAP-1") that binds directly to the retinoblastoma protein pocket of the underphosphorylated form of the retinoblastoma protein ("RB") and does not bind to phosphorylated RB or to RB with inactivating mutations. The translated RBAP-1 sequence does not resemble other proteins whose sequences are known, and RBAP-1 does not contain a sequence homologous to the transforming element common to viral proteins that bind to the RB pocket. RBAP-1 and the E2F transcription activity have similar DNA-binding specificities and can bind to at least some of the same proteins, such as RB and E4.

Abstract: We have discovered a nuclear protein in normal human cells, "retinoblastoma-associated protein 1" ("RBAP-1"), also known as E2F-1, that binds directly to the retinoblastoma protein pocket of the underphosphorylated form of the retinoblastoma protein ("RB") and does not bind to phosphorylated RB or to RB with inactivating mutations. The translated RBAP-1 sequence does not resemble other proteins whose sequences are known, and RBAP-1 does not contain a sequence homologous to the transforming element common to viral proteins that bind to the RB pocket. RBAP-1 and the E2F transcription activity have similar DNA-binding specificities and can bind to at least some of the same proteins, such as RB and E4.

Abstract: An electrical distribution load center consists of a non-conductive enclosure and a circuit breaker bus bar support panel that are interconnected by interlock members that can be snap-fitted to secure the two panels to each other. The support panel also has a latch member so that the bus bars can be mounted onto the panel in a heat-staking, insert-molded or snap-fit arrangement. The support panel also has elements for locking the circuit breakers onto the panels in conducting contact with the bus bars. The enclosure and the support panel are enclosed by a non-metallic trim panel that has a non-metallic door hinged thereto and which carries a latch for latching the door to the trim panel.

Abstract: A slug detection and prevention apparatus 10 and method therefor, which includes a detector 1, high pass filter 2, low pass filter 3, half-wave rectifier 4, comparator 5, and relay 6. Detector 1, being an accelerometer, condenser microphone, or the like, is electrically connected to high pass filter 2. High pass filter 2 is electrically connected to a low pass filter 3 whose output is electrically connected to a half-wave rectifier 4. The output of half-wave rectifier 4 is electrically connected to a comparator 5 which is also electrically connected to a separate voltage source, the magnitude of which corresponds to the energy present in the pass band or a normally operating compressor. The output of comparator 5 is electrically connected to relay 6 which controls the operation of compressor 7. The vibration wave form of compressor 7 is monitored by detector 1 whose signal is filtered to produce an output between apparoximately 80 and 305 hertz.