Abstract: The present disclosure provides antibodies that bind to ALK1 and methods/uses of the disclosed antibodies for treating various conditions (e.g., atherosclerosis). The present disclosure provides anti-ALK1 antibodies, comprising the complementarity determining regions (CDRs) of a heavy chain variable sequence and a light chain variable sequence selected from: the heavy chain variable sequence of SEQ ID NO: 2 and the light chain variable sequence of SEQ ID NO: 3. In some embodiments, the disclosed antibodies bind to human ALK1, murine ALK1, cynomolgus ALK1, or a combination thereof. The present disclosure also provides pharmaceutical compositions comprising an anti-ALK1 antibody accordingly to any one of the foregoing aspects or embodiments and a pharmaceutically acceptable carrier.

Abstract: The present invention relates to previously unknown biological roles of Nogo-B. We have discovered that Nogo-B is a component of endothelial cells. We have also discovered that Nogo-B is highly expressed in intact blood vessels. The amino terminus of Nogo-B promotes the adhesion, spreading and migration of endothelial cells and plays a role in vascular remodeling. Thus, Nogo-B is a novel regulator of vascular homeostasis and remodeling. The present invention provides compositions comprising Nogo-B and fragments and fusion proteins thereof. The present invention also relates to nucleic acids encoding Nogo-B and fragments and fusion proteins thereof, as well as vectors and cells comprising such nucleic acids. The present invention also relates to antibodies specific for Nogo-B and fragments and fusion proteins thereof. The present invention also provides methods for preventing, detecting and treating Nogo-B-related diseases, disorders and conditions.

Abstract: The invention describes isolated transport peptides, which cross the cell membrane of a cell and/or home to a target cell. The invention also describes a transport complex in which a transport peptide is linked to a cargo moiety to be delivered into/to a cell. Methods are disclosed describing delivery of a transport complex into and/or to a cell. Vectors and host cells comprising transport peptides and transport complexes are also described, as well as pharmaceutical compositions including transport complexes of the present invention.

Abstract: The invention relates to compositions and methods for facilitating fusion of a virus with a cell and for facilitating virus-mediated transduction of a nucleic acid into a cell. The invention further relates to the use of cell permeable peptides to facilitate fusion of a virus with a cell.