Abstract: Biometric feedback systems and methods for measuring user reaction to the indoor or outdoor environment are described. In some embodiments, one or more user(s) wears a body-worn sensor and the user's heart rate variability or other indication of stress is monitored as the user travels along a pre-determined route.

Abstract: A system and method are disclosed for measuring embodied stress relative to a location. The method comprises receiving stress data from sensors of monitoring devices, building a locational model from mapping data, receiving location data correlated with the stress data, filtering the stress data and the location data by comparing the location data to a locational model, aggregating the filtered stress data and the filtered location data into groups according to bins defined by a grid, analyzing the stress data and the location data to associate the stress data with the location data according to the locational model, generating a stress visualization based on the stress data and the location data; and deriving an emotion of one or more locations according to the locational model. The method further performs a locational sequence analysis by tracking stress changes along a sequence of locations to plan reductions of stress levels.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: The present disclosure provides compositions and methods for treating an auditory disease in a subject in need thereof comprising administering an effective amount of a gel-based precursor that includes an inner ear-specific therapeutic compound directly into the cochlea of the subject.

Abstract: An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.

Abstract: An improved metallic lamp socket enclosure of the cap-and-shell type for incandescent lamps is disclosed. According to the invention, the cap portion of the unit is provided with integral means for attaching a ground wire for safety purposes. The invention may be applied to units as they are manufactured or to previously manufactured units.A tool for forming the grounding means, and for effecting the attachment of a ground wire thereto, is also described.