Abstract: Devices, systems, and methods may be configured to image a reactant array using an imaging system that includes a wide-angle field of view. The system may include a substrate including the reactant array and a reader device having a wide-angle imaging system with the wide-angle field of view. The wide-angle imaging system may be configured to capture an image of the reactant array along an optical path through the wide-angle field of view. The reactant array may be on a planar or non-planar surface of the substrate. The wide-angle imaging system may include, a wide-angle lens, a flat imaging sensor, and one or more illumination sources. The reader device may include a housing configured to house at least part of the imaging system.

Abstract: Devices, systems, and methods may be utilized for analyzing a reactant array positioned along a first optical path or a second optical path. An example device may include a housing and an imaging system within the housing. The imaging system may include the first optical path and the second optical path. The imaging system may be configured to capture an image for analysis along one or both of the first optical path and the second optical path.

Abstract: Devices, systems, and methods may include or use a fixed imaging system with a window defining a window plane and an image sensor proximal of the window plane. The fixed imaging system may include or may be used with an optical relay positioned between the window plane and an object plane. The fixed imaging system may be configured to capture an image of an object at the object plane along an optical path through the window plane and the optical relay. The object may be a reactant array, which may be on a substrate. A housing may be configured to receive the substrate and position the reactant array at the object plane.

Abstract: Concentrating devices, systems, and methods include those for separating fluids to be sensed (e.g., analytes, such as volatile organic compounds (VOCs) and/or other chemical substances) from other fluid (e.g., a carrier gas, air, etc.) of a fluid mixture received from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, the concentration system may include a housing and a rotor positioned in a compartment of the housing. The housing may receive a fluid mixture in the compartment and rotation of the rotor relative to the housing may separate fluid to be sensed in the fluid mixture from other fluid of the fluid mixture.

Abstract: Concentrating devices, systems, and methods include those for separating fluids to be sensed (e.g., analytes, such as volatile organic compounds (VOCs) and/or other chemical substances) from other fluid (e.g., a carrier gas, air, etc.) of a fluid mixture received from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, the concentration system may include a housing and a rotor positioned in a compartment of the housing. The housing may receive a fluid mixture in the compartment and rotation of the rotor relative to the housing may separate fluid to be sensed in the fluid mixture from other fluid of the fluid mixture.

Abstract: Devices, systems, and methods include a system for analyzing reactant arrays. The system may include a cartridge including a reactant array and a device for analyzing the reactant array when the cartridge is received by or in the device. The cartridge may include a compartment for receiving a specimen that is in fluid communication with the reactant array and an opening configured to receive a sample portion of the specimen. The system may include the specimen having the sample portion configured to be positioned in the compartment and a non-sample portion extending out of the compartment.

Abstract: Devices, systems, and methods include a reactant array. The reactant array may include a sintered material and a reactant material applied to the sintered material. The reactant material may be configured to change one or more properties in response to exposure to one or more analytes. The reactant array may be used to identify an analyte of a fluid to which the reactant material is exposed based on a change in one or more properties of the reactant material in response to exposure to the fluid. The reactant array may be applied to a multi-dimensional object and passively and/or actively exposed to the fluid.

Abstract: Devices, systems, and methods include a system comprising a substrate having a transparent portion, one or more reactants on a first surface of the transparent portion of the substrate, a light source, and a light collector. The light source may be configured to illuminate the one or more reactants through the transparent portion of the substrate and the light collector may be configured to collect light from the one or more reactants. The light from the one or more reactants may be collected from the reactants without the light from the reactants traveling through the substrate and/or may be collected from the reactants after the light from the reactants has passed through the substrate.

Abstract: Devices, systems, and methods include a system for analyzing a target area. The system may include an opaque member having one or more slits configured to be transverse to a target area, one or more lenses configured to receive light from the target area, and an image sensor configured to receive the light from the target area that has passed through the one or more slits and the one or more lenses. A controller may be in communication with the image sensor to process and/or monitor sensed light. The system may include an optical system that includes the opaque member and the one or more lenses, which may have a first set of lenses and a second set of lenses. The target area may include a substrate supporting one or more reactants. The system may be a Fourier transform hyperspectral imaging fluid analysis system.

Abstract: Devices, systems, and methods include a system for analyzing reactant arrays (e.g., reactant arrays of colorimetric sensor arrays). The system may include a cartridge including a reactant array and a device for analyzing the reactant array when the cartridge is received by or in the device. The cartridge may include input port, an output port, and a component between the input port and the output port. The device may be configured to engage the pump component to pump fluid through a pathway in fluid communication with the input port, the output port, and the reactant array. The reactant array may include one or more reactants (e.g., analyte sensitive material).

Abstract: Devices, systems, and methods include a system comprising a light source directed at a surface, a spectrometer configured to measure, over time, levels of light collected from the surface, a controller in communication with the spectrometer. The controller may be configured to identify a component of fluid in contact with the surface based on the levels of the wavelengths of light collected from the surface.

Abstract: Concentrating devices, systems, and methods include those for separating fluids to be sensed (e.g., analytes, such as volatile organic compounds (VOCs) and/or other chemical substances) from other fluid (e.g., a carrier gas, air, etc.) of a fluid mixture received from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, the concentration system may include a housing and a rotor positioned in a compartment of the housing. The housing may receive a fluid mixture in the compartment and rotation of the rotor relative to the housing may separate fluid to be sensed in the fluid mixture from other fluid of the fluid mixture.

Abstract: Detection devices, systems, and methods include those for detecting analytes (e.g., volatile organic compounds (VOCs) and/or other chemical substances) from a target area of a subject's anatomy (e.g., a subject's skin, a wound on a subject, etc.). In some cases, a detector may have a detecting component that includes an analyte sensitive material applied to a substrate. The detector may be used with a pump. The detector may include a hydrophobic, gas permeable material configured to limit liquid reaching the analyte sensitive material, while allowing analytes in gaseous fluid to reach the analyte sensitive material.

Abstract: Collection devices, systems, and methods include those for collecting volatile organic compounds (VOCs) and/or other chemical substances from a target area of a subject’s anatomy (e.g., a subject’s skin, a wound on a subject, etc.). In some cases, the collector may have a collection component including an adsorbent material. The collector may be used with a pump. The pump may be configured to draw a fluid flow containing one or more chemical substances from a target area on a subject’s anatomy through the collection component. The collection component may be configured to collect at least some of the chemical substances from the fluid flow as the flow passes through the collection component.

Abstract: In one embodiment, a wavefront sensor is combined with a slit lamp eye examination device so that real time aberration values of an eye being examined can be viewed during a slit lamp eye examination session.

Abstract: A wavefront sensor includes a light source configured to illuminate a subject eye, a detector, a first beam deflecting element configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source and configured to direct a portion of the wavefront from the subject eye through an aperture toward the detector and a controller, coupled to the light source and the beam deflecting element, configured to control the beam deflecting element to deflect and project different portions of an annular ring portion of the wavefront from the subject eye through the aperture and further configured to pulse the light source at a firing rate to sample selected portions of the annular ring at the detector.

Abstract: One embodiment is a method for finding, calculating and electronically marking a reference axis for astigmatism correction/neutralization of a patient eye during a refractive surgery. The reference axis for astigmatism correction/neutralization can be determined intra-operatively based on one or more eye property measurements together with simultaneous recording a live eye image. The determined reference axis of astigmatism correction/neutralization can be updated and registered with one or more land mark(s) of the recorded eye image(s); and overlaid onto a live image of the eye. Another embodiment is a method of calculating and displaying in real time compensated refractive errors of the eye under operation with refractive components due to temporary surgically induced factors removed and refractive components due to surgeon-induced factors added.

Abstract: Example embodiments of a large dynamic range sequential wavefront sensor for vision correction or assessment procedures are disclosed. An example embodiment includes first and second optically coupled 4F relays and a variable focus lens disposed substantially at the image plane of the first 4F relay and the object plane of the second 4F relay.

Abstract: A wavefront sensor includes a light source configured to illuminate a subject eye, a detector, a first beam deflecting element configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source and configured to direct a portion of the wavefront from the subject eye through an aperture toward the detector and a controller, coupled to the light source and the beam deflecting element, configured to control the beam deflecting element to deflect and project different portions of an annular ring portion of the wavefront from the subject eye through the aperture and further configured to pulse the light source at a firing rate to sample selected portions of the annular ring at the detector.