Patents by Inventor William Sheffield

William Sheffield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8008257
    Abstract: A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin amino acid sequence. Also provided is a nucleic acid molecule encoding the fusion protein and a vector comprising the nucleic acid molecule. Methods for treating or preventing cardiovascular or renal disease comprising administration of an effective amount of the fusion protein, or nucleic acid encoding the fusion protein, are also disclosed.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: August 30, 2011
    Assignees: University of Ottawa Heart Institute, McMaster University
    Inventors: Adolfo J. De Bold, Mercedes L. Kuroski De Bold, William Sheffield
  • Publication number: 20070162986
    Abstract: A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin amino acid sequence. Also provided is a nucleic acid molecule encoding the fusion protein and a vector comprising the nucleic acid molecule. Methods for treating or preventing cardiovascular or renal disease comprising administration of an effective amount of the fusion protein, or nucleic acid encoding the fusion protein, are also disclosed.
    Type: Application
    Filed: October 20, 2006
    Publication date: July 12, 2007
    Inventors: Adolfo De Bold, Mercedes Kuroski De Bold, William Sheffield
  • Publication number: 20050202770
    Abstract: An abrasive sheet member is disclosed, including a substrate having first and second major surfaces, an abrasive on the first major surface, and a plurality of hooking stems on the second major surface. The hooking stems are adapted to hook engaging structures on an opposed surface to releasably affix the abrasive sheet member to the surface.
    Type: Application
    Filed: April 20, 2005
    Publication date: September 15, 2005
    Inventors: Jason Chesley, Donald Bell, Harold Rude, William Sheffield, David Slama, Alan Stephens
  • Patent number: 5035056
    Abstract: A utensil or tool specifically adapted for slicing bananas includes a frame which circumscribes an area generally conforming to the shape and size of a typical banana. The frame has two opposing curvilinear longitudinal sides which are interconnected with a plurality of spaced, substantially parallel disposed ribs. The ribs are sufficiently thin to cut transversely through a banana when the utensil is pushed down on a banana. The utensil is held by a user through handles which are attached to ends of the frame. An elongated hole is provided in one of the handles to permit hanging of the utensil on a peg board or the like for storage.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: July 30, 1991
    Inventor: William Sheffield