Patents by Inventor William Siegel

William Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12180270
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: December 31, 2024
    Assignee: Eli Lilly and Company
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Publication number: 20240059770
    Abstract: Provided herein are novel N- and C-terminal oxyntomodulin polypeptide binding molecules, and uses thereof, including a method for quantitating oxyntomodulin.
    Type: Application
    Filed: January 19, 2022
    Publication date: February 22, 2024
    Inventors: Robert John KONRAD, Wenyu MING, Robert William SIEGEL, II, Tara Suzanne UMBERGER
  • Patent number: 11802117
    Abstract: Methods of converting CBD to ?8-THC to ?10-THC to ?6a10a-THC are described and the products disclosed. Various adjustments can be made to the reactions resulting in increased or decreased product and by-product.
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: October 31, 2023
    Inventors: Alexander William Siegel, Alek Enrique Valle, Devin Jay Wall
  • Publication number: 20230220062
    Abstract: The present invention provides compounds and methods targeting human interleukin-19, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications useful in the field of immune-mediated diseases including psoriasis, atopic dermatitis, psoriatic arthritis, bronchial asthma and diabetic nephropathy.
    Type: Application
    Filed: January 25, 2023
    Publication date: July 13, 2023
    Inventors: Richard Earl HIGGS, Jr., Robert John KONRAD, Brian Jeffrey NICKOLOFF, Robert William SIEGEL, II
  • Publication number: 20230064132
    Abstract: Methods of converting CBD to ?8-THC to ?10-THC to ?6a10a-THC are described and the products disclosed. Various adjustments can be made to the reactions resulting in increased or decreased product and by-product.
    Type: Application
    Filed: August 26, 2021
    Publication date: March 2, 2023
    Inventors: Devin Jay WALL, Alek Enrique VALLE, Alexander William Siegel
  • Patent number: 11591387
    Abstract: The present invention provides compounds and methods targeting human interleukin-19, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications useful in the field of immune-mediated diseases including psoriasis, atopic dermatitis, psoriatic arthritis, bronchial asthma and diabetic nephropathy.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: February 28, 2023
    Assignee: Eli Lilly and Company
    Inventors: Richard Earl Higgs, Jr., Robert John Konrad, Brian Jeffrey Nickoloff, Robert William Siegel, II
  • Patent number: 11492395
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 fusion proteins are disclosed. Nucleic acid constructs encoding ANGPTL3/8 fusion proteins also are disclosed. Methods of making and using the same also are disclosed, especially for generating antibodies against ANGPTL3 and/or ANGPTL8.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: November 8, 2022
    Assignee: Eli Lilly and Company
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Publication number: 20220146535
    Abstract: The present invention provides compounds and methods targeting human tau, particularly human tau phosphorylated at threonine 217 and isoforms of tau expressed only in the CNS, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications useful in the field of neurodegenerative diseases such as AD, PSP and FTD.
    Type: Application
    Filed: November 24, 2021
    Publication date: May 12, 2022
    Inventors: Xiyun CHAI, Jinbiao CHEN, Jeffrey L. Dage, David Albert Driver, Steven Fisher Hinton, Robert William Siegel, II, Peter Edward Vaillancourt
  • Publication number: 20220110537
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Publication number: 20220089560
    Abstract: Compositions of ?10-THC and ?6a10a-THC are prepared and described. The conversions do not affect existing CBD or CBG in the extract. Various adjustments can be made to the reactions resulting in increased or decreased product and by-product. Various formulations with medical uses are disclosed.
    Type: Application
    Filed: September 22, 2020
    Publication date: March 24, 2022
    Inventors: Alexander William Siegel, Devin Jay Wall, Alek Enrique Valle
  • Patent number: 11242383
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: February 8, 2022
    Assignee: Eli Lilly and Company
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Publication number: 20210147530
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Application
    Filed: January 19, 2021
    Publication date: May 20, 2021
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Patent number: 10919959
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodes bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: February 16, 2021
    Assignee: Eli Lilly and Company
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Patent number: 10894780
    Abstract: Methods of converting ?9-THC to ?10-THC are described and the products disclosed. The methods do not affect existing CBD or CBG in the extract. Various adjustments can be made to the reactions resulting in increased or decreased product and by-product.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 19, 2021
    Inventors: Alexander William Siegel, Alek Enrique Valle, Devin Jay Wall
  • Publication number: 20200354444
    Abstract: The present invention provides compounds and methods targeting human interleukin-19, including therapeutic antibodies, pharmaceutical compositions and diagnostic applications useful in the field of immune-mediated diseases including psoriasis, atopic dermatitis, psoriatic arthritis, bronchial asthma and diabetic nephropathy.
    Type: Application
    Filed: June 17, 2020
    Publication date: November 12, 2020
    Inventors: Richard Earl Higgs, JR., Robert John Konrad, Brian Jeffrey Nickoloff, Robert William Siegel, II
  • Publication number: 20200199213
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 25, 2020
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Publication number: 20200199212
    Abstract: Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodes bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.
    Type: Application
    Filed: December 13, 2019
    Publication date: June 25, 2020
    Inventors: Qing Chai, Jonathan Wesley Day, Robert John Konrad, Yuewei Qian, Oliver Schroeder, Robert William Siegel
  • Patent number: 8832707
    Abstract: An attribute of a descriptor associated with a task informs a runtime environment of which instructions a processor is to run to schedule a plurality if resources for completion of the task in accordance with a level of quality of service in a service level agreement.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 9, 2014
    Assignee: International Business Machines Corporation
    Inventors: Daniel J. Henderson, Prabhakar N. Kudva, Naresh Nayar, Pia Naoko Sanda, David William Siegel, James Van Oosten, James Xenidis
  • Publication number: 20060018519
    Abstract: A hand-held personal identification device is provided. The hand-held personal identification device includes a sensor system for gathering biometric information from individuals, a profiler system for developing profiles of individuals based on biometric information gathered from the sensor system, and a personal data assistant or similar computing device with a screen for providing a user interface and overall system control. A sensor system interface couples the sensor system to the computer module.
    Type: Application
    Filed: July 12, 2005
    Publication date: January 26, 2006
    Applicant: Cross Match Technologies, Inc.
    Inventors: William Siegel, Ronnie Leighty, Christian Liautaud, Aleksandr Sorokin, Timothy McDow
  • Publication number: 20060013447
    Abstract: A hand-held personal identification analysis device is provided. The hand-held personal identification analysis device includes a scanning system for gathering biometric information from individuals, a profiler system for developing profiles of individuals based on biometric information gathered from the scanning system, and a personal data assistant or similar computing device with a screen for providing a user interface and overall system control A scanning system interface couples the scanning system to said computer module.
    Type: Application
    Filed: April 4, 2005
    Publication date: January 19, 2006
    Applicant: Cross Match Technologies, Inc.
    Inventors: William Siegel, Ronnie Leighty, Christian Liautaud, Aleksandr Sorokin, Timothy McDow