Patents by Inventor William Sikkema

William Sikkema has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11246962
    Abstract: Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 15, 2022
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, William Sikkema
  • Publication number: 20200222453
    Abstract: Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.
    Type: Application
    Filed: April 30, 2018
    Publication date: July 16, 2020
    Applicants: WILLIAM MARSH RICE UNIVERSITY, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, BAYLOR COLLEGE OF MEDICINE, HOUSTON METHODIST RESEARCH INSTITUTE, THE UNITED STATES GOVERNMENT
    Inventors: James M. TOUR, Lizanne NILEWSKI, William SIKKEMA, Kimberly MENDOZA, Thomas Andrew KENT, William DALMEIDA, Jr., Paul J. DERRY, Ah-Lim TSAI, Muralidhar L. HEGDE, Prakash DHARMALINGAM, Pavana Dixit HEGDE, Sankar MITRA, Joy MITRA
  • Publication number: 20190184063
    Abstract: Graphene compositions used for neuronal repair and treatments, and, in particular neuronal scaffold-water soluble graphene for treatment of severed spinal cords and other neuronal repairs. The neuronal scaffold-water soluble graphene can be PEGylated GNR used in combination with a fusogen agent, such as PEG600.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 20, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: James M. Tour, William Sikkema