Patents by Inventor William Sisk

William Sisk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of transport of therapeutic molecules across the blood brain barrier
    Patent number: 9676849
    Abstract: The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 13, 2017
    Assignee: Biogen MA Inc.
    Inventors: Graham K. Farrington, William Sisk
  • ENHANCEMENT OF TRANSPORT OF THERAPEUTIC MOLECULES ACROSS THE BLOOD BRAIN BARRIER
    Publication number: 20150210762
    Abstract: The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.
    Type: Application
    Filed: January 10, 2013
    Publication date: July 30, 2015
    Inventors: Graham K. Farrington, William Sisk
  • Expression cassette and vector for transient or stable expression of exogenous molecules
    Publication number: 20060141625
    Abstract: The disclosure provides an expression cassette and a vector comprising the cassette for expression of a polynucleotide. The expression cassette includes a promoter/enhancer, an intervening region, and a polyadenylation signal domain. Expression systems and methods of using the expression cassette and vector are also provided.
    Type: Application
    Filed: February 13, 2004
    Publication date: June 29, 2006
    Applicant: Biogen Idec MA Inc.
    Inventors: William Sisk, Holly Prentice
  • Neublastin expression constructs
    Publication number: 20050158824
    Abstract: A method of producing a secreted neublastin polypeptide using a heterologous signal sequence is disclosed. The secreted neublastin does not contain a neublastin pro sequence.
    Type: Application
    Filed: October 1, 2004
    Publication date: July 21, 2005
    Inventors: Nels Pederson, William Sisk