Patents by Inventor William Solvibile

William Solvibile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9592221
    Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: March 14, 2017
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES
    Publication number: 20160263083
    Abstract: The invention provides compounds of formula Ia, Ib and Ic: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Application
    Filed: March 8, 2016
    Publication date: September 15, 2016
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, PROVID PHARMACEUTICALS INC.
    Inventors: Richard H. EBRIGHT, Yon W. EBRIGHT, Juan SHEN, James BACCI, Anne-Cecile HIEBEL, William SOLVIBILE, Christopher SELF, Gary OLSON
  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9315495
    Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 19, 2016
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES
    Publication number: 20150197512
    Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Application
    Filed: June 19, 2013
    Publication date: July 16, 2015
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • Substituted 4-(Indazol-3-yl)phenols
    Publication number: 20070225349
    Abstract: This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the inflammatory component of diseases and are particularly useful in treating atherosclerosis, myocardial infarction, congestive heart failure, inflammatory bowel disease, arthritis, type II diabetes, and autoimmune diseases such as multiple sclerosis and rheumatiod arthritis.
    Type: Application
    Filed: May 16, 2007
    Publication date: September 27, 2007
    Applicant: Wyeth
    Inventors: Robert Steffan, Edward Matelan, Mark Ashwell, William Solvibile
  • Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation
    Publication number: 20070004786
    Abstract: The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Applicant: Wyeth
    Inventors: Michael Malamas, Ping Zhou, William Fobare, William Solvibile, Iwan Gunawan, James Erdei, Yinfa Yan, Patrick Andrae, Dominick Quagliato
  • Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators
    Publication number: 20060183792
    Abstract: The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of ?-secretase (BACE) and for the treatment of ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: February 13, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: William Fobare, William Solvibile
  • Amino-pyridines as inhibitors of beta-secretase
    Publication number: 20060173049
    Abstract: The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit ?-secretase (BACE) and treat ?-amyloid deposits and neurofibrillary tangles.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 3, 2006
    Applicant: Wyeth
    Inventors: Michael Malamas, William Fobare, William Solvibile, Frank Lovering, Jeffrey Condon, Albert Robichaud
  • Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines
    Publication number: 20060025436
    Abstract: Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
    Type: Application
    Filed: June 17, 2005
    Publication date: February 2, 2006
    Applicant: Wyeth
    Inventors: Brian Ridgway, William Moore, Mark Ashwell, William Solvibile, Amy Lee, Molly Hoke, Madelene Antane, Amedeo Failli