Abstract: In accordance with one aspect of the disclosure, an image analysis system is provided. The image analysis system includes at least one processor configured to access image tiles associated with a patient, each tile comprising a portion of a whole slide image, individually provide a first group of image tiles to a first trained model, receive a first set of feature objects from the first trained model, cluster feature objects from the first set of feature objects to form a number of clusters, calculate a number of attention scores based on the first set of feature objects, select a second group of tiles, individually provide the second group of image tiles to a second trained model, receive a second set of feature objects from the second trained model, generate a cancer grade indicator, and cause the cancer grade indicator to be output.