Abstract: Improved sensor compositions comprising a dye are provided. The compositions are generally characterized by at least partially immobilizing the dye on polymeric microparticles and dispersing in a dispersion medium. The dye may comprise an oxygen, humidity, carbon dioxide, temperature, or pH-responsive dye. Also provided is a sensor patch comprising a substrate and the sensor composition comprising a dye.

Abstract: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an antibody that specifically binds to an antigenic site on venom present in the sample. Binding is then detected. The invention is illustrated by examples showing diagnosis of brown recluse spider bite, distinguishing it from other diagnoses with which it is often confused. This extremely sensitive test can detect venom antigens down to about 20 picograms even after the sample has been shipped and stored for periods of up to three weeks during the summer.

Abstract: Improved methods for computer-aided analysis of identifying features of skin lesions from digital images of the lesions are provided. Improved preprocessing of the image that 1) eliminates artifacts that occlude or distort skin lesion features and 2) identifies groups of pixels within the skin lesion that represent features and/or facilitate the quantification of features are provided including improved digital hair removal algorithms. Improved methods for analyzing lesion features are also provided.

Abstract: A method and apparatus for casting a molten material using a phase-change material. A funnel means is provided that includes a reservoir containing a phase-change material. The funnel means is used in conjunction with a mold. The phase-change material is heated to a temperature above its melting point. A molten material is poured into the mold, and an excess amount of the molten material is retained in the funnel means after the mold is filled. The latent heat of fusion of the phase-change material provides heat to the funnel means as the phase-change material changes from a liquid to a solid. The heat from the phase-change material maintains the temperature of the molten material within the funnel above its melting point as the molten material within the mold begins to solidify and contract, thereby permitting the excess material within the funnel means to feed into the mold and fill any voids or porosities formed by the contraction of the material within the mold.

Abstract: A method and apparatus for casting a molten material using a phase-change material. A funnel means is provided that includes a reservoir containing a phase-change material. The funnel means is used in conjunction with a mold. The phase-change material is heated to a temperature above its melting point. A molten material is poured into the mold, and an excess amount of the molten material is retained in the funnel means after the mold is filled. The latent heat of fusion of the phase-change material provides heat to the funnel means as the phase-change material changes from a liquid to a solid. The heat from the phase-change material maintains the temperature of the molten material within the funnel above its melting point as the molten material within the mold begins to solidify and contract, thereby permitting the excess material within the funnel means to feed into the mold and fill any voids or porosities formed by the contraction of the material within the mold.