Abstract: Disclosed herein are sortilin binding agents, including conjugate agents comprising a sortilin binding moiety, directly or indirectly conjugated with a payload moiety, compositions comprising the same as well as methods of making and using the same.

Abstract: A computing device includes: a housing defining a battery chamber; an electrical contact disposed on a wall of the battery chamber; a latch extending into the battery chamber, the latch movable between (i) a first position to retain a battery pack within the battery chamber and engage the battery pack with the electrical contact, and (ii) a second position to disengage from the battery pack; an auxiliary retainer in communication with the battery chamber, the auxiliary retainer configured to retain the battery pack within the battery chamber, independently of the latch, via engagement with a complementary retaining structure of the battery pack.

Abstract: A dock for a computing device includes: a housing including a cradle end wall defining a closed end of a channel configured to receive a computing device along a travel direction, and a rear cradle wall extending between the cradle end wall and an open end of the channel; a latch movably supported at the rear cradle wall between (i) an engaged position extending into the channel to engage with the computing device, and (ii) a retracted position withdrawn from the channel to disengage from the computing device; a bias member configured to bias the latch towards the engaged position to automatically engage with the computing device in response to insertion of the computing device into the channel; and an actuator coupled to the latch, the actuator configured to transition the latch to the disengaged position for releasing the computing device from the channel.

Abstract: An input assembly for a computing device includes: an input device; a mounting body coupled to the input device; a blade member affixed to the mounting body, the blade member configured for insertion into a slot of the computing device, wherein the slot includes a transverse recess; a latch disposed within the blade member, the latch having a head carrying a magnet, the latch coupled to the mounting body movably between (i) an engaged position to place the head in the recess and obstruct withdrawal of the latch from the slot, and (ii) a retracted position to withdraw the head from the recess; and wherein the latch is biased towards the engaged position via attraction between the magnet and a magnetic material of the transverse recess.

Abstract: A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

Abstract: A package comprising a first metallization portion, a first integrated device coupled to the first metallization portion, a second integrated device coupled to the first metallization portion, a second metallization portion coupled to the first metallization portion through a first plurality of pillar interconnects, a first chiplet located between the first metallization portion and the second metallization portion, wherein the first chiplet is configured to be electrically coupled to the first integrated device through the first metallization portion, and a second chiplet located between the first metallization portion and the second metallization portion, wherein the second chiplet is configured to be electrically coupled to the second integrated device through the first metallization portion.

Abstract: A package comprising a first metallization portion, a first integrated device coupled to the first metallization portion through a first plurality of pillar interconnects, and a first chiplet located between the first integrated device and the first metallization portion. The first chiplet is coupled to the first integrated device through a first plurality of inter pillar interconnects. The first chiplet may include an active chiplet. The first chiplet may include a passive chiplet.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: An AI-based system and method for feed monitoring in a land-based fish farm, where the fish farm has a tank containing fish and an effluent pipe that is coupled to the tank where uneaten feed pellets and non-pellet objects flow through the effluent pipe to an exit port. A feed camera is mounted to an effluent pipe for capturing a video feed having images of objects that traverse a field of view of the feed camera when each image is acquired. A special-purpose computer executes a pellet-tracking algorithm that employs a region of interest (ROI) proposal module, an ROI classification module, an ROI tracking module, and a trajectory classification module for at least counting uneaten feed pellets. The computer generates in real time a pellet count based on the pellet trajectories.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: A package comprising a first integrated device comprising a plurality of first pillar interconnects; an encapsulation layer at least partially encapsulating the first integrated device; a metallization portion located over the first integrated device and the encapsulation layer, wherein the metallization portion includes at least one passivation layer and a plurality of metallization layer interconnects, wherein the plurality of first pillar interconnects is coupled to the plurality of metallization layer interconnects; and a second integrated device comprising a plurality of second pillar interconnects, wherein the second integrated device is coupled to the plurality of metallization layer interconnects through a plurality of second pillar interconnects and a plurality of solder interconnects.

Abstract: An organization has or uses an SLA system that selects a service-level agreement (SLA) that should apply to a given user request. The SLA system then can monitor the state of the ticket created based on the user request and provide messages or other feedback to the agent to aid the agent in meeting any performance goals associated with the SLA. The SLA system can determine the SLA to associate with a given user request by inferring a type of the request and selecting the SLA based on the type, or by using a model to directly associate an SLA to a given user request, without the need to infer an intermediate type for the user request, which eliminates the need for administrators to create and maintain metadata to guide the association between types and SLAs.

Abstract: A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

Abstract: A package comprising a first integrated device comprising a plurality of first pillar interconnects; an encapsulation layer at least partially encapsulating the first integrated device; a metallization portion located over the first integrated device and the encapsulation layer, wherein the metallization portion includes at least one passivation layer and a plurality of metallization layer interconnects, wherein the plurality of first pillar interconnects is coupled to the plurality of metallization layer interconnects; and a second integrated device comprising a plurality of second pillar interconnects, wherein the second integrated device is coupled to the plurality of metallization layer interconnects through a plurality of second pillar interconnects and a plurality of solder interconnects.

Abstract: Integrated circuit (IC) packages employing a capacitor-embedded, redistribution layer (RDL) substrate and related fabrication methods. The embedded capacitor can be coupled to a power distribution network (PDN) to provide decoupling capacitance to reduce current-resistance (IR) drop. The RDL substrate is disposed between the IC chip(s) and the package substrate to minimize distance between the embedded capacitor(s) and the IC chip(s) to reduce the parasitic inductance in the PDN, thus reducing PDN noise. With the RDL substrate disposed between the package substrate and the IC chip(s), the RDL substrate needs to support through-interconnections between the package substrate and the IC chip(s). In this regard, the RDL substrate includes an outer RDL layer adjacent to the IC chip(s) to support small pitch metal interconnects as well as provide fan-out capability.

Abstract: Embodiments for an AI-based system and method for feed monitoring in a land-based fish farm are described where the system may include: a feed camera mounted to an effluent pipe for capturing a video feed having images of objects that traverse a field of view of the feed camera when each image is acquired; and a special-purpose computer that executes a pellet-tracking algorithm that employs a region of interest (ROI) proposal module, an ROI classification module, an ROI tracking module, and a trajectory classification module for at least counting uneaten feed pellets. In at least one embodiment, an object enhancer may be mounted to the effluent pipe opposite to and in the field of view of the feed camera to provide a background so that the objects in the acquired images have a definable perimeter.

Abstract: A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

Abstract: The present disclosure provides binding agents, such as antibodies, that specifically bind ILT2, ILT4, or both ILT2 and ILT4, as well as compositions comprising the binding agents, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising the binding agents.

Abstract: A method of making CBD concentrate or CBD Isolate comprises (a) milling a raw material; (b) contacting the milled raw material with an extraction solvent and separating a solid waste material to form a filtered extract; (c) concentrating the filtered extract; (d) washing the concentrated extract to form an organic phase and an aqueous phase; (e) separating the aqueous phase from the organic phase to form a washed extract; (f) removing an organic solvent from the washed extract to form a concentrated washed extract; (g) decarboxylating the concentrated washed extract; (h) vacuum distilling the decarboxylated extract to form a distillate; (i) dewaxing the distillate to form a post-dewax filtrate; (j) applying a vacuum to the post-dewax filtrate to form a post-dewax concentrate; (k) degassing the post-dewax concentrate; and (l) vacuum distilling the degassed concentrate to form a CBD concentrate.

Abstract: Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant function for vaccine administration. LMP1 or LMP1-CD40 chimeric protein may be used to activate and mature dendritic cells. LMP1 and LMP1-activated dendritic cells act as an adjuvant to enhance the cellular immune response. Also disclosed herein are kits for activating dendritic cells and for preparing a vaccine formulation. Administration of the dendritic cells transfected with LMP1 can induce an immune response against cancer or infection. The mature dendritic cells may comprise an antigen and at least one cytokine in addition to LMP1. Use of LMP1 or LMP1-CD40 provides a way to activate and mature dendritic cells that retain functional and migratory abilities without the side effects that result from maturing the dendritic cells using PGE2.