Patents by Inventor William Sun

William Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060240020
    Abstract: The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab?)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
    Type: Application
    Filed: June 29, 2006
    Publication date: October 26, 2006
    Inventors: Michael Fung, William Sun, Cecily Sun
  • Publication number: 20060194321
    Abstract: The present invention provides methods for the directed differentiation of embryonic stem cells along the endodermal lineage, especially the pancreatic lineage.
    Type: Application
    Filed: January 30, 2006
    Publication date: August 31, 2006
    Inventors: Alan Colman, William Sun, Norris Dunn, Blaine Phillips, Hentze Martin, William Rust
  • Publication number: 20060177366
    Abstract: NOx and SO3 emissions from combustion of a sulfur containing carbonaceous fuel are reduced simultaneously. The combustion gases comprising NOx and SO2 are mixed with a NOx control agent into the combustion gases at a point upstream of a selective catalytic reduction catalyst for reduction of NOx. Following an SCR catalyst or other equipment that can oxidize SO2 to SO3 and prior to contact with an air heater for heating incoming combustion air, magnesium hydroxide is introduced in amounts and with droplet sizes and concentrations effective to form nano-sized particles in the effluent and reduce SO3 caused by the oxidation of SO2 in the catalyst. Computational fluid dynamics is employed to determine flow rates and select reagent introduction rates, reagent introduction location(s), reagent concentration, reagent droplet size and/or reagent momentum.
    Type: Application
    Filed: February 6, 2006
    Publication date: August 10, 2006
    Inventors: Christopher Symrniotis, William Sun
  • Publication number: 20060115402
    Abstract: A preferred apparatus arrangement utilizes the enthalpy of the flue gas, which can be supplemented if need be, to convert urea (30) into ammonia for SCR. Urea (30), which decomposes at temperatures above 140.degree. C., is injected (32) into a flue gas stream split off (28) after a heat exchanger (22), such as a primary superheater or an economizer. Ideally, the side stream would gasify the urea without need for further heating; but, when heat is required it is far less than would be needed to heat either the entire effluent (23) or the urea (30). This side stream, typically less than 3% of the flue gas, provides the required temperature and residence time for complete decomposition of urea (30). A cyclonic separator can be used to remove particulates and completely mix the reagent and flue gas. This stream can then be directed to an injection grid (37) ahead of SCR using a blower (36).
    Type: Application
    Filed: February 8, 2006
    Publication date: June 1, 2006
    Applicant: FUEL TECH, INC.
    Inventors: William Sun, William Cummings, Piers de Havilland, Paul Carmignani, John Boyle
  • Publication number: 20050232920
    Abstract: The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab?)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
    Type: Application
    Filed: May 27, 2005
    Publication date: October 20, 2005
    Inventors: Michael Fung, William Sun, Cecily Sun
  • Publication number: 20050124859
    Abstract: A tongue stabilizer includes a tongue-engaging plate that is held on a laryngoscope blade by pressure sensitive adhesive, with a foam strip in-between to compensate for any irregularities between the tongue-engaging plate and the laryngoscope blade. The tongue-engaging plate is cup shape to cradle the tongue to prevent the tongue from interfering with the visibility and process of intubation. A protective strip can be used to cover the adhesive.
    Type: Application
    Filed: December 9, 2003
    Publication date: June 9, 2005
    Inventor: William Sun
  • Publication number: 20050084871
    Abstract: This invention relates to novel human organic anion transporter polypeptides and genes encoding such polypeptides. The invention is directed towards the isolation, characterization and use of human organic anion transporter polypeptides for pharmacological screening of substrates, analogues of substrates, and modulators of human organic anion proteins. This invention also provides cell cultures, which stably contain nucleic acid sequences encoding human organic anion transport polypeptides. Such cell lines are useful for screening compounds in vitro to identify and characterize modulators, inhibitors and substrates of human organic anion transporter polypeptides.
    Type: Application
    Filed: November 24, 2003
    Publication date: April 21, 2005
    Inventor: William Sun
  • Patent number: 6680379
    Abstract: This invention relates to novel human organic anion transporter polypeptides and genes encoding such polypeptides. The invention is directed towards the isolation, characterization and use of human organic anion transporter polypeptides for pharmacological screening of substrates, analogues of substrates, and modulators of human organic anion proteins. This invention also provides cell cultures, which stably contain nucleic acid sequences encoding human organic anion transport polypeptides. Such cell lines are useful for screening compounds in vitro to identify and characterize modulators, inhibitors and substrates of human organic anion transporter polypeptides.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: January 20, 2004
    Assignee: Metabasis Therapeutics, Inc.
    Inventor: William Sun
  • Patent number: 6664086
    Abstract: To elucidate molecular mechanisms in learning and memory, the expression of mRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of the transcription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blocked learning but not performance of the CR. Differential display PCR (DD-PCR) analysis of cerebellar RNAs from trained and pseudo-trained rabbits identified a 207-bp band that was induced with learning. The fragment was used to isolate a cDNA from a &lgr;gt11 rabbit brain library containing a 1698-bp open-reading frame. The genomic sequence also has been obtained and is reported. The deduced amino acid sequence contains the KKIAMRE motif, which is conserved among cdc2-related kinases. These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: December 16, 2003
    Assignee: University of Southern California
    Inventors: Richard F. Thompson, Hirishi Gomi, William Sun
  • Publication number: 20030166220
    Abstract: To elucidate molecular mechanisms in learning and memory, the expression of mRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of the transcription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blocked learning but not performance of the CR. Differential display PCR (DD-PCR) analysis of cerebellar RNAs from trained and pseudo-trained rabbits identified a 207-bp band that was induced with learning. The fragment was used to isolate a cDNA from a &lgr;gt11 rabbit brain library containing a 1698-bp open-reading frame. The genomic sequence also has been obtained and is reported. The deduced amino acid sequence contains the KKIAMRE motif, which is conserved among cdc2-related kinases. These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory.
    Type: Application
    Filed: June 18, 2002
    Publication date: September 4, 2003
    Inventors: Richard F. Thompson, Hiroshi Gomi, William Sun
  • Patent number: 6428994
    Abstract: To elucidate molecular mechanisms in learning and memory, the expression of mRNAs in brains of rabbitsundergoing eyeblink conditioning was analyzed. Infusion of the transcription inhibitor actinomycin D (ActD) into the cerebellar nuclei reversibly blocked learning but not performance of the CR. Differential display PCR (DD-PCR) analysis of cerebellar RNAs from trained and pseudo-trained rabbits identified a 207-bp band that was induced with learning. The fragment was used to isolate a cDNA from a &lgr;gt11 rabbit brain library containing a 1698-bp open-reading frame. The genomic sequence also has been obtained and is reported. The deduced amino acid sequence contains the KKIAMRE motif, which is conserved among cdc2-related kinases. These results suggest that there is a new category of cdc2-related kinases in the brain whose function may be important in learning and memory.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: August 6, 2002
    Assignee: University of Southern California
    Inventors: Richard F. Thompson, Hirishi Gomi, William Sun