Patents by Inventor William T. Pu

William T. Pu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TAZ GENE OR ENZYME REPLACEMENT THERAPY
    Publication number: 20230211015
    Abstract: Provided herein, in some aspects, are compositions and methods for treating Barth syndrome (BTHS) using human tafazzin gene therapy or enzyme replacement therapy. The present disclosure, in some aspects, provides compositions and methods (e.g., gene therapy or enzyme replacement therapy) for treating Barth syndrome (BTHS). It was demonstrated herein that certain human Tafazzin (hTAZ) isoforms and the full length protein, as well as nucleic acids encoding them, are effective in treating BTHS.
    Type: Application
    Filed: February 12, 2021
    Publication date: July 6, 2023
    Applicant: Children's Medical Center Corporation
    Inventors: William T. Pu, Suya Wang
  • MYBPC3 POLYPEPTIDES AND USES THEREOF
    Publication number: 20220023384
    Abstract: Provided herein are compositions and methods for treating a disorder associated with abnormal RYR2 function (e.g., arrhythmia or heart failure). In some embodiments, method comprises administering to a subject in need thereof an effective amount of a polypeptide comprising a C-terminal domain of Cardiac Myosin binding protein C (MYBPC3) or a nucleic acid or an rAAV encoding such polypeptide.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 27, 2022
    Applicant: Children's Medical Center Corporation
    Inventors: William T. Pu, Fujian Lu, Vassilios Bezzerides
  • Compositions and methods for evaluating and treating heart failure
    Publication number: 20090306181
    Abstract: The invention relates to compositions, formulations, kits, and methods useful for the treatment and evaluation of heart disease in an individual.
    Type: Application
    Filed: September 28, 2007
    Publication date: December 10, 2009
    Applicant: Children's Medical Center Corporation
    Inventors: Sadakatsu Ikeda, William T. Pu, Sek Won Kong