Abstract: An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two-dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume.

Abstract: The invention relates to a method for the preparation of particles comprising a gas core and shell which particles are suitable for use as contrast agent and as part of a therapeutic composition, especially for drug delivery. These particles show a surprisingly high activation level on provision of ultrasound energy.

Abstract: An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two-dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume.