Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.

Abstract: A powder melting device for an additive manufacturing system is provided. The powder melting device includes at least one laser device configured to generate at least one energy beam for forming at least one melt pool in a layer of powdered material. The powder melting device also includes at least two optical elements configured to dynamically induce beam distortion in the at least one energy beam to modify a beam spot incident on the layer of powdered material. The at least two optical elements are configured to induce at least one of an aspect ratio adjustment of the at least one energy beam, an optical powder redistribution between a periphery and a center of the at least one energy beam, and a rotation of the at least one energy beam.

Abstract: In one example, an apparatus comprises a backplane to attach an array of light emitting diodes (LED), the backplane comprising an array of display driver circuits, each display driver circuit of the array of display driver circuits corresponding to an LED of the array of LEDs and comprising: a current driver circuit configured to supply to a current to the corresponding LED; a control signal generator circuit configured to supply a driver control signal to the current driver circuit to control the current; and one or more monitor circuits controllable to provide access to at least one of: the current, or an internal voltage of at least one of the current driver circuit or the control signal generator circuit.

Abstract: Methods of manufacturing or repairing a turbine blade or vane are described. The airfoil portions of these turbine components are typically manufactured by casting in a ceramic mold, and a surface made up of the cast airfoil and at the least the ceramic core serves as a build surface for a subsequent process of additively manufacturing the tip portions. The build surface is created by removing a top portion of the airfoil and the core, or by placing an ultra-thin shim on top of the airfoil and the core. The overhang projected by the shim is subsequently removed. These methods are not limited to turbine engine applications, but can be applied to any metallic object that can benefit from casting and additive manufacturing processes. The present disclosure also relates to finished and intermediate products prepared by these methods.

Abstract: Techniques are described for operating a display comprising an array of emitters arranged in at least one column. A data shifting circuit stores digital data or an analog representation thereof in a first storage element. The data shifting circuit outputs the digital data or analog representation multiple times to a display driver circuit, using a multiplexer. The first storage element can be a shift register or a capacitor. Digital data can be internally shifted within the data shifting circuit, through multiple shift registers, prior to output to the display driver circuit. An analog representation can be stored and read from the same capacitor without internal shifting. The display driver circuit drives a different emitter of the column each time. A scanning assembly including a reflective surface that receives light from the emitter array forms an output image by rotating the reflective surface in synchronization with driving of the emitters.

Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. A system includes an introducer tool including a dilator portion, a carrier portion and a release mechanism, the dilator portion selectively engageable with the carrier portion. The system further includes a lead including a lead body and an electrode structure, the electrode structure including an active side with an electrode disposed thereon, and an inactive side with an element disposed thereon. The introducer tool is configured to be temporarily inserted into a patient over a guidewire, and a portion of the release mechanism is selectively engageable with the element of the electrode structure to retain the electrode structure to the introducer tool.

Abstract: A system includes a plurality of first LEDs, a plurality of second LEDs, a first controllable current source that is configured to generate a first bias current for driving a first one of the plurality of first LEDs and a plurality of first ones of the plurality of second LEDs, a first measurement circuit that is configured to measure a first current-voltage (I-V) performance characteristic of the first one of the plurality of first LEDs, and a lens that is arranged to receive light from the plurality of second LEDs. A property of the first bias current is determined as a function of at least two measurements of the first I-V performance characteristic that are acquired while the first bias current is applied to the first one of the plurality of first LEDs and the plurality of first ones of the plurality of second LEDs.

Abstract: A direct metal laser melting (DMLM) system includes a rotatable base, and a build plate mounted on and supported by the rotatable base, where the build plate includes a build surface. The DMLM system also includes a first actuator assembly, a first powder dispenser disposed proximate the build plate and configured to deposit a weldable powder on the build surface of the build plate. In addition, the DMLM system includes a first powder spreader disposed proximate the build plate and configured to spread the weldable powder deposited on the build surface of the build plate, and a first laser scanner supported by the first actuator assembly in a position relative to the build plate, such that at least a portion of the build surface is within a field of view of the first laser scanner. The first laser scanner is configured to selectively weld the weldable powder. The first laser scanner is further configured to translate axially relative to the build surface on the first actuator assembly.

Abstract: A composition comprising at least one AAV vector formulated for intrathecal delivery to the central nervous system is described. The composition comprises at least one expression cassette which contains sequences encoding an immunoglobulin construct linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn).

Abstract: A refrigeration appliance includes a compartment for storing food items in a refrigerated environment, the compartment being illuminated by at least one modular LED illumination device. The portion of the illumination device disposed within the compartment is generally flush with a mounting section and includes an LED lighting module arranged in a housing. The module has a board member, two or more LED light sources electrically connected to one another and to the board member, and two or more electrical edge connections for allowing electrically parallel connection between two or more modules being interchangeable with one another. A concave reflecting surface is positioned adjacent the module with a majority of light emitted from the LED light sources being incident thereon for reflection into the compartment. A liner defining the compartment has the mounting section to which the housing is mounted, where the mounting section has an inward draft angle.

Abstract: A method may include: sending a first signal representing a message identifying an entity from a server computer system to a resource usage tracking server; in response to the message, receiving, from the resource usage tracking server, a second signal representing historical resource usage data for the entity; identifying a first data transfer recipient associated with the historical resource usage data for the entity by using a database of supported data transfer recipients; sending a third signal, the third signal causing a client device associated with the entity to display a selectable option for data transfer to the identified first data transfer recipient; receiving a fourth signal, the fourth signal indicating selection of the selectable option for data transfer to the identified first data transfer recipient; and in response to receiving the fourth signal, configuring an account associated with the entity based on the first data transfer recipient.

Abstract: An authentication system for authenticating a water filter cartridge at an appliance is provided. The water filter cartridge comprises a connection assembly having one or more connection devices that are structured for engaging an electrical connector of an appliance water filter manifold assembly of an appliance, to establish an electrical connection between the connection assembly and a controller of the appliance. A method of use of the water filter cartridge at the appliance comprises inserting the water filter cartridge into a receptacle of an appliance water filter manifold assembly. A method of authentication of the water filter cartridge comprises establishing an electrical communication link between a memory device of a water filter cartridge and an appliance water filter manifold assembly of the appliance, and retrieving, via the electrical communication link, a unique identifier associated with the water filter cartridge from the memory device.

Abstract: A device to measure the range of motion of any joint with accuracy without having to place the device exactly on the joint to be measured. The device comprises of an internal measurement unit which measures the change in motion and send the information to the microprocessor which processes the information to accurately show the range of motion to within a degree, and the speed and acceleration with which the movement of the joint occurred. The microprocessor then sends the range of motion, speed and acceleration to an external device to be displayed. The external device then displays a 2-D or 3-D rendering of the movement.

Abstract: In some aspects, a method of authoring an interactive presentation includes defining a sequence of two or more primary content items within a presentation, and associating a link to additional content with a primary content item of the sequence in a non-transitory computer-readable medium. In additional aspects, a method of delivering an interactive presentation includes accessing the sequence of two or more primary content items, delivering the primary content items to a presentation device, and delivering, to applications operating on mobile devices of audience members, the primary content items with the additional content and/or one or more links thereto. In further aspects, a method of interacting with an interactive presentation includes receiving, by a mobile device of an audience member, a sequence of primary content items with additional content and/or one or more links thereto, and displaying the received primary content items and the additional content.

Abstract: A wire harness assembly including a first connector, a second connector, and conductors extending between the first connector and the second connector. Contacts are provided on the second connector. The contacts have termination sections which are mounted on the second connector, compliant sections which extend from the termination sections, and substrate engagement sections which extend from the compliant sections. The substrate engagement sections have curved contact sections which are configured to be positioned in mechanical and electrical engagement with circuit pads of a mating printed circuit board. Embossments are provided on the curved contact sections to provide additional strength and stability to the curved contact sections.

Abstract: Described herein are systems, devices, methods, and media for transmitting emergency alerts, emergency services requests, and emergency data associated with emergency alerts and emergency service requests to relevant parties, such monitoring centers and emergency service providers.

Abstract: In some embodiments, a method for performing enhancement on an audio signal to generate an enhanced audio signal in response to feedback indicative of amount of compression applied to at least one frequency band of the enhanced audio signal. In typical embodiments, the enhancement is or includes bass enhancement. Examples of other types of enhancement performed in other embodiments include dialog enhancement, upmixing, frequency shifting, harmonic injection or transposition, subharmonic injection, virtualization, and equalization Other aspects are systems (e.g., programmed processors) and devices (e.g., devices having physically-limited bass reproduction capabilities, such as, for example, a notebook, tablet, mobile phone, or other device with small speakers) configured to perform any embodiment of the method.

Abstract: A method of forming a build in a powder bed includes emitting a plurality of laser beams from selected fibers of a diode laser fiber array onto the powder bed, the selected fibers of the array corresponding to a pattern of a layer of the build; and simultaneously melting powder in the powder bed corresponding to the pattern of the layer of the build.